PDF(Pubmed)
Abstract：
Semiconductor nanomaterials have emerged as a significant factor in the advancement of tumor immunotherapy. This review discusses the potential of transition metal oxide (TMO) nanomaterials in the realm of anti-tumor immune modulation. These binary inorganic semiconductor compounds possess high electron mobility, extended ductility, and strong stability. Apart from being primary thermistor materials, they also serve as potent agents in enhancing the anti-tumor immunity cycle. The diverse metal oxidation states of TMOs result in a range of electronic properties, from metallicity to wide-bandgap insulating behavior. Notably, titanium oxide, manganese oxide, iron oxide, zinc oxide, and copper oxide have garnered interest due to their presence in tumor tissues and potential therapeutic implications. These nanoparticles (NPs) kickstart the tumor immunity cycle by inducing immunogenic cell death (ICD), prompting the release of ICD and tumor-associated antigens (TAAs) and working in conjunction with various therapies to trigger dendritic cell (DC) maturation, T cell response, and infiltration. Furthermore, they can alter the tumor microenvironment (TME) by reprogramming immunosuppressive tumor-associated macrophages into an inflammatory state, thereby impeding tumor growth. This review aims to bring attention to the research community regarding the diversity and significance of TMOs in the tumor immunity cycle, while also underscoring the potential and challenges associated with using TMOs in tumor immunotherapy.
摘要：
半导体纳米材料已成为肿瘤免疫治疗发展的重要因素。本文综述了过渡金属氧化物（TMO）纳米材料在抗肿瘤免疫调节领域的潜力。这些二元无机半导体化合物具有高电子迁移率，扩展延性，稳定性强。除了是主要的热敏电阻材料，它们也是增强抗肿瘤免疫周期的有效药物。TMO的不同金属氧化态导致一系列的电子特性，从金属性到宽带隙绝缘行为。值得注意的是,氧化钛,氧化锰，氧化铁，氧化锌，和氧化铜由于它们在肿瘤组织中的存在和潜在的治疗意义而引起了人们的兴趣。这些纳米颗粒（NPs）通过诱导免疫原性细胞死亡（ICD）启动肿瘤免疫周期，促使ICD和肿瘤相关抗原（TAA）的释放，并与各种疗法结合以触发树突状细胞（DC）成熟，T细胞反应，和渗透。此外，它们可以通过将免疫抑制性肿瘤相关巨噬细胞重编程为炎症状态来改变肿瘤微环境（TME），从而阻碍肿瘤生长。这篇综述旨在引起研究界对TMO在肿瘤免疫周期中的多样性和意义的关注。同时也强调了在肿瘤免疫治疗中使用TMO的潜力和挑战。
