Korean Red Ginseng Improves Oxidative Stress-Induced Hepatic Insulin Resistance via Enhancing Mitophagy.

韩国红参通过增强线粒体自噬改善氧化应激诱导的肝脏胰岛素抵抗。

• 影响指数: 5.561
• 发表时间: 2024 Jul 5
• 来源期刊: Foods
• DOI: 10.3390/foods13132137
• PMID: 38998642
• 文章类型: Journal Article
• 作者列表: Rustamov N,Ma Y,Park JS,Wang F,Ma H,Sui G,Moon G,Yoo HS,Roh YS

关键词: Korean Red Ginseng; PINK1/Parkin pathway; insulin resistance; mitophagy; oxidative stress

Abstract

This study explored the potential of saponins from Korean Red Ginseng to target the PINK1/Parkin mitophagy pathway, aiming to enhance insulin sensitivity in hepatocytes-a key factor in metabolic disorders like metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes. Results from both in vitro and in vivo experiments showed increased expression of PINK1 and Parkin, activating mitophagy and reducing oxidative stress through reduction in mitochondrial and total reactive oxygen species. Additionally, improvements in insulin signaling were observed, including the upregulation of phosphorylated IRS and AKT, and downregulation of gluconeogenic enzymes, underscoring the saponins\' efficacy in boosting insulin sensitivity. The findings highlighted Korean Red Ginseng-derived saponins as potential treatments for insulin resistance and related metabolic conditions.

摘要

本研究探索了韩国红参皂苷靶向PINK1/Parkin线粒体自噬途径的潜力，旨在增强肝细胞的胰岛素敏感性-代谢障碍如代谢功能障碍相关的脂肪变性肝病（MASLD）和2型糖尿病的关键因素。体外和体内实验的结果表明，PINK1和Parkin的表达增加，通过减少线粒体和总活性氧来激活线粒体自噬和减少氧化应激。此外,观察到胰岛素信号的改善，包括磷酸化IRS和AKT的上调，和糖异生酶的下调，强调皂苷在提高胰岛素敏感性方面的功效。研究结果强调了韩国红参衍生的皂苷作为胰岛素抵抗和相关代谢条件的潜在治疗方法。