PDF(Pubmed)
Abstract：
The extraction of bioactive compounds from wine lees involves a variety of methods, the selection of which is crucial to ensure optimal yields. This systematic review, following PRISMA guidelines and utilizing the Web of Science database, aimed to examine the current state of this field, providing insights for future investigations. The search employed strategies with truncation techniques and Boolean operators, followed by a three-step screening using well-defined eligibility criteria. A bibliometric analysis was conducted to identify authors, affiliations, countries/regions, and research trends. Thirty references were selected for analysis, with Spain standing out as the main source of research on the topic. The majority of studies (66%) focused on the extraction of bioactive compounds from alcoholic fermentation lees, while 33% were directed towards malolactic fermentation lees. Binary mixtures (ethanol-water) were the predominant solvents, with ultrasound being the most used extraction method (31.3%), providing the highest average yields (288.6%) for the various evaluated compounds, especially flavonoids. The potential of wine lees as a source of bioactive compounds is highlighted, along with the need for further research exploring alternative extraction technologies and the combination of methods. Additionally, the importance of \"in vitro\" and \"in vivo\" tests to assess the bioactive potential of lees, as well as the use of computational tools to optimize extraction and identify the molecules responsible for bioactive activity, is emphasized.
摘要：
从酒糟中提取生物活性化合物涉及多种方法，选择哪种产品对于确保最佳产量至关重要。本系统综述,遵循PRISMA指南并利用WebofScience数据库，旨在研究这一领域的现状，为未来的调查提供见解。搜索采用了带有截断技术和布尔运算符的策略，然后使用明确的合格标准进行三步筛查.进行了文献计量分析，以确定作者，从属关系，国家/地区,和研究趋势。选择了30个参考文献进行分析，西班牙是该主题研究的主要来源。大多数研究（66％）集中在从酒精发酵酒糟中提取生物活性化合物，而33%的人针对苹果酸乳酸发酵酒糟。二元混合物（乙醇-水）是主要的溶剂，超声波是最常用的提取方法(31.3%)，提供各种评估化合物的最高平均产率（288.6%），尤其是类黄酮.突出了酒糟作为生物活性化合物来源的潜力，随着需要进一步研究探索替代提取技术和方法的结合。此外,“体外”和“体内”测试评估酒糟生物活性潜力的重要性，以及使用计算工具来优化提取和识别负责生物活性的分子，强调。
