PDF(Pubmed)
Abstract：
Numerous natural antioxidants commonly found in our daily diet have demonstrated significant benefits for human health and various diseases by counteracting the impact of reactive oxygen and nitrogen species. Their chemical properties enable a range of biological actions, including antihypertensive, antimicrobial, anti-inflammatory, anti-fibrotic, and anticancer effects. Despite promising outcomes from preclinical studies, ongoing debate persists regarding their reproducibility in human clinical models. This controversy largely stems from a lack of understanding of the pharmacokinetic properties of these compounds, coupled with the predominant focus on monotherapies in research, neglecting potential synergistic effects arising from combining different antioxidants. This study aims to provide an updated overview of natural antioxidants, operating under the hypothesis that a multitherapeutic approach surpasses monotherapy in efficacy. Additionally, this study underscores the importance of integrating these antioxidants into the daily diet, as they have the potential to prevent the onset and progression of various diseases. To reinforce this perspective, clinical findings pertaining to the treatment and prevention of non-alcoholic fatty liver disease and conditions associated with ischemia and reperfusion phenomena, including myocardial infarction, postoperative atrial fibrillation, and stroke, are presented as key references.
摘要：
我们日常饮食中常见的许多天然抗氧化剂通过抵消活性氧和氮物质的影响，已经证明对人类健康和各种疾病有显著的益处。它们的化学性质使一系列生物作用成为可能，包括抗高血压药,抗菌，抗炎,抗纤维化，和抗癌作用。尽管临床前研究取得了有希望的结果，关于它们在人类临床模型中的可重复性的争论持续存在.这一争议主要源于对这些化合物的药代动力学特性缺乏了解，再加上研究中主要关注单一疗法，忽略了不同抗氧化剂组合产生的潜在协同效应。这项研究旨在提供天然抗氧化剂的最新概述，在多治疗方法疗效优于单一治疗的假设下进行操作。此外,这项研究强调了将这些抗氧化剂融入日常饮食的重要性，因为它们有可能预防各种疾病的发生和发展。为了加强这种观点，关于治疗和预防非酒精性脂肪性肝病以及与缺血和再灌注现象相关的疾病的临床发现，包括心肌梗塞,术后心房颤动,和中风，作为关键参考。
