PDF(Pubmed)
Abstract：
The CoCrFeMnNi high-entropy alloy is commonly used for vascular stents due to its excellent mechanical support and ductility. However, as high-entropy alloy stents can cause inflammation in the blood vessels, leading to their re-narrowing, drug-eluting stents have been developed. These stents have nanopores on their surfaces that can carry drug particles to inhibit inflammation and effectively prevent re-narrowing of the blood vessels. To optimize the mechanical properties and drug-carrying capacity of high-entropy alloy stents, a high-entropy alloy system with different wide and deep square-shaped nanopore distributions is created using molecular dynamics. The mechanical characteristics and dislocation evolution mechanism of different nanopore high-entropy alloy systems under tensile stress were studied. The results showed that the CoCrFeMnNi high-entropy alloy with a rational nanopore distribution can effectively maintain the mechanical support required for a vascular stent. This research provides a new direction for the manufacturing process of nanopores on the surfaces of high-entropy alloy stents.
摘要：
CoCrFeMnNi高熵合金由于其优异的机械支撑和延展性而通常用于血管支架。然而,因为高熵合金支架会引起血管炎症，导致它们重新缩小，已经开发了药物洗脱支架。这些支架在其表面上具有纳米孔，可以携带药物颗粒以抑制炎症并有效防止血管重新变窄。为优化高熵合金支架的力学性能和载药能力,使用分子动力学创建具有不同宽和深方形纳米孔分布的高熵合金系统。研究了不同纳米孔高熵合金体系在拉应力作用下的力学特性和位错演化机理。结果表明，纳米孔分布合理的CoCrFeMnNi高熵合金可以有效地维持血管支架所需的机械支撑。该研究为高熵合金支架表面纳米孔的制造工艺提供了新的方向。
