PDF(Pubmed)
Abstract：
Reports on neoplasms in bears are scarce, especially concerning ovarian tumors. A large primary ovarian neoplasm with multiple metastasis was found during the necropsy of a 14-year-old free-ranging Eurasian brown bear (Ursus arctos) from Northwestern Spain. Histopathology and immunohistochemistry allowed for the diagnosis of a sex cord stromal tumor. This is a complex group of neoplasms which differ in the predominant cell morphology and immunohistochemical features. The microscopic examination revealed two types of cells, one with eosinophilic cytoplasm, intermingled with larger vacuolated cells rich in lipids. The evaluation of the immunoreactivity to different markers, frequently used in the characterization of gonadal tumors (INHA, inhibin-alpha; PLAP, placental alkaline phosphatase; Ki-67; α-SMA, actin alpha-smooth muscle) and inflammation patterns (IBA1, ionized calcium-binding adapter molecule for macrophages; CD3 for T lymphocytes; CD20 for B lymphocytes), displayed significant INHA positive immunostaining of neoplastic cells, as well as inflammatory cell infiltration, mainly composed of macrophages and B lymphocytes. These findings were consistent with a malignant ovarian steroid cell tumor, not otherwise specified. The present study characterizes an unusual type of neoplasm, and also represents the first report of an ovarian sex cord stromal tumor in Ursidae.
摘要：
关于熊肿瘤的报道很少，尤其是卵巢肿瘤。在对来自西班牙西北部的14岁自由放养的欧亚棕熊（Ursusarctos）进行尸检时，发现了一个大的原发性卵巢肿瘤，并伴有多个转移。组织病理学和免疫组织化学可以诊断性索间质肿瘤。这是一组复杂的肿瘤，其主要细胞形态和免疫组织化学特征不同。显微镜检查显示两种类型的细胞，一个有嗜酸性细胞浆，与富含脂质的较大的空泡细胞混合。对不同标记的免疫反应性的评价，常用于性腺肿瘤的表征(INHA，抑制素-α;PLAP,胎盘碱性磷酸酶;Ki-67;α-SMA,肌动蛋白α-平滑肌）和炎症模式（IBA1，巨噬细胞的离子化钙结合接头分子；CD3用于T淋巴细胞；CD20用于B淋巴细胞），显示肿瘤细胞的显著INHA阳性免疫染色，以及炎症细胞浸润，主要由巨噬细胞和B淋巴细胞组成。这些发现与恶性卵巢类固醇细胞肿瘤一致，未指定。本研究描述了一种不寻常类型的肿瘤，也代表了Ursidae卵巢性索间质肿瘤的首次报道。
