Abstract：
In this study, the curcumin was firstly encapsulated in gelatin (GLT) and/or cellulose nanocrystals (CNC) stabilized emulsions, then further mixed with sodium alginate (SA) to form emulsion-filled hydrogel beads loaded with curcumin (Cur). The Cur-loaded emulsions showed a droplet size of 20.3-24.4 μm with a uniform distribution. Introducing CNC and/or SA increased the viscosity of emulsions accompanied by viscoelastic transition, while the modulus was reduced due to destruction of GLT gel. Cur was doubly immobilized in the hydrogel beads with >90 % of encapsulation efficiency. The results of simulated gastrointestinal tract experiments revealed that the beads possessed a good pH sensitivity and controlled release behavior to prolong the retention of Cur in the gastrointestinal tract. After 6 h of UV irradiation, the Cur-loaded emulsion-filled hydrogel beads showed a higher antioxidant activity than that of pure Cur, effectively delaying the photodegradation of Cur. In addition, the beads had better stability in aqueous and acidic environments, which was favorable for prolonging the release of Cur. These results suggest that the emulsion-filled hydrogel beads have great potential for the delivery of lipophilic bioactive molecules.
摘要：
在这项研究中,姜黄素首先封装在明胶（GLT）和/或纤维素纳米晶体（CNC）稳定的乳液中，然后进一步与藻酸钠(SA)混合以形成加载有姜黄素(Cur)的乳液填充的水凝胶珠粒。负载Cur的乳液显示出具有均匀分布的20.3-24.4μm的液滴尺寸。引入CNC和/或SA会增加乳液的粘度，并伴有粘弹性转变，而模量由于GLT凝胶的破坏而降低。Cur以>90%的包封效率双重固定在水凝胶珠粒中。模拟胃肠道实验结果表明，微珠具有良好的pH敏感性和控释行为，延长了Cur在胃肠道中的滞留时间。紫外线照射6小时后，负载Cur的乳液填充水凝胶珠显示出比纯Cur更高的抗氧化活性，有效延缓Cur的光降解。此外,珠子在水性和酸性环境中具有更好的稳定性，这有利于延长Cur的释放。这些结果表明,乳液填充的水凝胶珠具有递送亲脂性生物活性分子的巨大潜力。
