METHODS: In this review, we will discuss how the two therapeutic approaches converge. We present a model by which (1) an inflammation is required for the appropriate pro-myelinating immune function of OPCs in the chronically inflamed CNS, and (2) the immune function of OPCs is crucial for their ability to differentiate and promote remyelination. This model highlights the reciprocal interactions between OPCs\' pro-myelinating and immune-modulating functions. Additionally, we review the specific effects of anti- and pro-inflammatory interventions on OPCs, suggesting that immunosuppression adversely affects OPCs\' differentiation and immune functions.
CONCLUSIONS: We suggest a multi-systemic therapeutic approach, which necessitates not a unidimensional focus but a harmonious balance between OPCs\' pro-myelinating and immune-modulatory functions.
方法:在这篇综述中,我们将讨论这两种治疗方法是如何融合的。我们提出了一个模型,通过该模型(1)慢性发炎的CNS中OPCs的适当的髓鞘形成免疫功能需要炎症,(2)OPCs的免疫功能对其分化和促进髓鞘再生的能力至关重要。该模型强调了OPCs前髓鞘形成和免疫调节功能之间的相互作用。此外,我们回顾了抗炎和促炎干预对OPCs的具体影响,表明免疫抑制对OPCs的分化和免疫功能产生不利影响。
结论:我们建议采用多系统治疗方法,这不需要一维聚焦,而是需要OPCs前髓鞘形成和免疫调节功能之间的和谐平衡。