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Abstract：
BACKGROUND: Recent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However, there have been no reports demonstrating the expression of NR1 subunit of the NMDA receptor in large cell neuroendocrine carcinoma (LCNEC).
METHODS: Here, we report the first elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with LCNEC of the lung with NR1 expression. Of note, NR1 subunit expression in the tumor cells of the present case was confirmed by immunohistochemistry (IHC). Radiation therapy and immunotherapies, such as corticosteroids and intravenous immunoglobulin (IVIG), shrank the tumors and improved neurological symptoms in the present case. Additionally, we also confirmed the expression of NR1 in the tumor cells obtained from three other cases with LCNEC of the lung at our hospital by IHC.
CONCLUSIONS: Our IHC results indicate that LCNEC generally expresses NR1 subunit and NMDA receptor may be involved in the tumor development and growth.
METHODS: Here, we report the first elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with LCNEC of the lung with NR1 expression. Of note, NR1 subunit expression in the tumor cells of the present case was confirmed by immunohistochemistry (IHC). Radiation therapy and immunotherapies, such as corticosteroids and intravenous immunoglobulin (IVIG), shrank the tumors and improved neurological symptoms in the present case. Additionally, we also confirmed the expression of NR1 in the tumor cells obtained from three other cases with LCNEC of the lung at our hospital by IHC.
CONCLUSIONS: Our IHC results indicate that LCNEC generally expresses NR1 subunit and NMDA receptor may be involved in the tumor development and growth.
摘要：
背景：最近的研究表明，N-甲基-D-天冬氨酸（NMDA）受体参与几种肿瘤的细胞增殖。然而,尚无报道证明大细胞神经内分泌癌（LCNEC）中NMDA受体NR1亚基的表达。
方法：这里，我们报告了第一例与NR1表达的肺LCNEC相关的副肿瘤性抗NMDA受体脑炎的老年病例。值得注意的是，通过免疫组织化学(IHC)证实了本病例的肿瘤细胞中的NR1亚基表达。放射治疗和免疫疗法，如皮质类固醇和静脉注射免疫球蛋白（IVIG），缩小肿瘤并改善神经系统症状。此外,我们还通过IHC证实了NR1在我们医院的其他3例肺部LCNEC患者的肿瘤细胞中的表达。
结论：我们的IHC结果表明LCNEC通常表达NR1亚基，NMDA受体可能参与肿瘤的发展和生长。
方法：这里，我们报告了第一例与NR1表达的肺LCNEC相关的副肿瘤性抗NMDA受体脑炎的老年病例。值得注意的是，通过免疫组织化学(IHC)证实了本病例的肿瘤细胞中的NR1亚基表达。放射治疗和免疫疗法，如皮质类固醇和静脉注射免疫球蛋白（IVIG），缩小肿瘤并改善神经系统症状。此外,我们还通过IHC证实了NR1在我们医院的其他3例肺部LCNEC患者的肿瘤细胞中的表达。
结论：我们的IHC结果表明LCNEC通常表达NR1亚基，NMDA受体可能参与肿瘤的发展和生长。
