PDF(Pubmed)
Abstract：
Vitamin D deficiency (VDD) is associated with increased risk of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We aimed to investigate the association between the triglyceride-glucose (TyG) index that represents IR and VDD in elderly patients with T2DM. We enrolled 572 elderly participants with T2DM in this study. TyG index was calculated as ln [fasting triglyceride (TG, mg/dL) × fasting blood glucose (mg/dL)/2]. Serum 25-hydroxyvitamin D [25(OH)D] level below 50 nmol/L was defined as VDD. The association between the TyG index and the VDD risk was evaluated by multivariate logistic regression analysis. We observed a significant decreased 25(OH)D level with the increase of the TyG index in elderly diabetic patients, and a negative correlation between the TyG index and 25(OH)D level. The participants in the highest TyG quartile had a 2.40-fold higher risk of VDD than those in the lowest TyG index quartile [OR 2.40; 95% CI 1.47-3.92; P < 0.001]. The association persisted after adjustments for age, sex, smoking, obesity, insulin therapy, hypoglycemic agents\' medication, and some biochemical parameters. TyG index may be involved in the pathophysiology of VDD, which could be a predictor for VDD in elderly diabetic patients.
摘要：
维生素D缺乏（VDD）与2型糖尿病（T2DM）和胰岛素抵抗（IR）的风险增加有关。我们旨在研究老年T2DM患者中代表IR的甘油三酯-葡萄糖（TyG）指数与VDD之间的关系。在这项研究中，我们招募了572名患有T2DM的老年参与者。TyG指数计算为ln[空腹甘油三酯(TG，mg/dL)×空腹血糖(mg/dL)/2]。血清25-羟基维生素D[25(OH)D]水平低于50nmol/L定义为VDD。通过多变量逻辑回归分析评估TyG指数与VDD风险之间的关联。我们观察到老年糖尿病患者25(OH)D水平随着TyG指数的增加而显著降低,TyG指数与25(OH)D水平呈负相关。最高TyG四分位数的参与者的VDD风险比最低TyG指数四分位数的参与者高2.40倍[OR2.40;95％CI1.47-3.92;P<0.001]。在调整了年龄后，协会仍然存在，性别,吸烟,肥胖，胰岛素治疗,降血糖药物，和一些生化参数。TyG指数可能与VDD的病理生理有关，这可能是预测老年糖尿病患者的VDD。
