PDF(Pubmed)
Abstract：
The relationship between the triglyceride glucose-body mass index (TyG-BMI) index and Alzheimer\'s disease (AD) pathology, cognition, and brain structure remains unclear. This study aimed to investigate these associations, focusing on cerebrospinal fluid (CSF) biomarkers, cognitive measures, and brain imaging data. Eight hundred and fifty-five non-demented participants were included. Linear regression was used to explore associations between the TyG-BMI index and AD pathology, cognition, and brain structure. The association between the TyG-BMI index and AD risk was assessed using Kaplan-Meier and Cox proportional hazards models. Longitudinal relationships were assessed using linear mixed-effects models. Mediation analyses were conducted to examine AD pathology\'s potential mediating role between the TyG-BMI index and cognition as well as brain structure. In the linear regression analyses, higher TyG-BMI levels were associated with increased Aβ42 and decreased Tau, pTau, Tau/Aβ42, pTau/Aβ42, and pTau/Tau. Positive correlations were observed with mini-mental state examination (MMSE), memory (MEM), executive function (EF), and the volumes of the hippocampus, entorhinal cortex, and middle temporal regions, while negative correlations were found with Alzheimer\'s Disease Assessment Scale (ADAS). Longitudinally, the TyG-BMI index was inversely associated with ADAS, and positively with MMSE, MEM, EF, hippocampus, entorhinal, and middle temporal. High TyG-BMI levels were correlated with lower AD risk (HR 0.996 [0.994, 0.999]). Mediation analyses revealed AD pathology mediated the association between TyG-BMI index and cognition as well as brain structure. Additionally, the TyG-BMI index could mediate cognitive changes by influencing brain structure. The TyG-BMI index is associated with AD pathology, cognition, and brain structure.
摘要：
甘油三酯葡萄糖-体重指数(TyG-BMI)指数与阿尔茨海默病(AD)病理的关系,认知，大脑结构仍不清楚。本研究旨在调查这些关联，专注于脑脊液（CSF）生物标志物，认知措施，和大脑成像数据。包括85名非痴呆参与者。用线性回归分析TyG-BMI指数与AD病理之间的关系。认知，和大脑结构。使用Kaplan-Meier和Cox比例风险模型评估TyG-BMI指数与AD风险之间的关联。使用线性混合效应模型评估纵向关系。进行了中介分析，以检查在TyG-BMI指数与认知以及大脑结构之间的AD病理学潜在中介作用。在线性回归分析中，较高的TyG-BMI水平与Aβ42升高和Tau降低相关，pTau,Tau/Aβ42、pTau/Aβ42和pTau/Tau。与简易精神状态检查(MMSE)呈正相关，内存(MEM),执行功能（EF），海马体的体积，内嗅皮层,和中部时间区域，而与阿尔茨海默病评估量表（ADAS）呈负相关。纵向,TyG-BMI指数与ADAS呈负相关，和积极的MMSE，MEM,EF,海马体,entorhinal,和中部时间。高的TyG-BMI水平与较低的AD风险相关（HR0.996[0.994,0.999]）。中介分析显示，AD病理介导了TyG-BMI指数与认知以及大脑结构之间的关联。此外,TyG-BMI指数可通过影响大脑结构介导认知改变。TyG-BMI指数与AD病理有关,认知，和大脑结构。
