Abstract：
Dendritic cells (DCs) play a central role in initiating and shaping the adaptive immune response, thanks to their ability to uptake antigens and present them to T cells. Once in the lymph node (LN), DCs can spread the antigen to other DCs, expanding the pool of cells capable of activating specific T-cell clones. Additionally, DCs can modulate the dynamics of other immune cells, by increasing naïve T-cell dwell time, thereby facilitating the scanning for cognate antigens, and by selectively recruiting other leukocytes. Here we discuss the role of DCs in orchestrating antigen and leukocyte trafficking within the LN, together with the implications of this trafficking on T-cell activation and commitment to effector function.
摘要：
树突状细胞（DC）在启动和塑造适应性免疫反应中起着核心作用。由于它们能够摄取抗原并将其呈递给T细胞。一旦进入淋巴结（LN），DC可以将抗原扩散到其他DC，扩增能够激活特定T细胞克隆的细胞池。此外,DC可以调节其他免疫细胞的动力学，通过增加幼稚T细胞停留时间，从而促进同源抗原的扫描，并通过选择性地招募其他白细胞。在这里，我们讨论了DCs在LN内协调抗原和白细胞运输中的作用，以及这种贩运对T细胞活化和对效应子功能的承诺的影响。
