Abstract：
BACKGROUND: Men with cystic fibrosis (CF) have sexual health concerns such as delayed puberty, infertility, and hypogonadism. The causes and prevalence of hypogonadism have not been well studied. The purpose of this study was to determine the prevalence of a low testosterone concentration in men with CF.
METHODS: This retrospective study was approved by the Emory University Institutional Review Board (IRB). Data were extracted from the electronic medical records of adult men with CF receiving care at the Emory Cystic Fibrosis Center. A total of 129 men with CF were followed at our center from 2016 to 2023. Of these individuals, 76 men with CF (58.9%) had at least one serum total testosterone measurement. Seven individuals were excluded from this study since they were currently receiving testosterone therapy, leaving a final sample size of 69 individuals for the analysis. Demographic data, serum testosterone concentrations, and other factors associated with low testosterone concentrations were collected. Low testosterone was defined as a value below 300 ng/dL. Regression analyses were used to determine factors associated with low testosterone levels.
RESULTS: The mean (± SD) age of the 69 eligible participants was 33.34 ± 10.98 years. The mean testosterone concentration was 421 ± 158.5 ng/dL with 27.54 percent of men with a testosterone value below 300 ng/dL. The mean hemoglobin level was 14.23 ± 2.18 g/dL. Testosterone levels were positively related to hemoglobin levels. Time of day of measurement and age were not associated with testosterone levels.
CONCLUSIONS: Roughly a quarter of men with CF demonstrated low testosterone in our sample. Low hemoglobin was associated with low testosterone levels in men with CF. Neither time of day nor age influenced testosterone concentrations in this sample.
METHODS: This retrospective study was approved by the Emory University Institutional Review Board (IRB). Data were extracted from the electronic medical records of adult men with CF receiving care at the Emory Cystic Fibrosis Center. A total of 129 men with CF were followed at our center from 2016 to 2023. Of these individuals, 76 men with CF (58.9%) had at least one serum total testosterone measurement. Seven individuals were excluded from this study since they were currently receiving testosterone therapy, leaving a final sample size of 69 individuals for the analysis. Demographic data, serum testosterone concentrations, and other factors associated with low testosterone concentrations were collected. Low testosterone was defined as a value below 300 ng/dL. Regression analyses were used to determine factors associated with low testosterone levels.
RESULTS: The mean (± SD) age of the 69 eligible participants was 33.34 ± 10.98 years. The mean testosterone concentration was 421 ± 158.5 ng/dL with 27.54 percent of men with a testosterone value below 300 ng/dL. The mean hemoglobin level was 14.23 ± 2.18 g/dL. Testosterone levels were positively related to hemoglobin levels. Time of day of measurement and age were not associated with testosterone levels.
CONCLUSIONS: Roughly a quarter of men with CF demonstrated low testosterone in our sample. Low hemoglobin was associated with low testosterone levels in men with CF. Neither time of day nor age influenced testosterone concentrations in this sample.
摘要：
背景：患有囊性纤维化（CF）的男性有性健康问题，例如青春期延迟，不孕症,和性腺功能减退.性腺机能减退的原因和患病率尚未得到很好的研究。这项研究的目的是确定患有CF的男性中低睾酮浓度的患病率。
方法：这项回顾性研究得到了埃默里大学机构审查委员会（IRB）的批准。数据是从Emory囊性纤维化中心接受治疗的CF成年男性的电子病历中提取的。从2016年到2023年，我们中心共跟踪了129名CF患者。在这些人中,76名CF男性（58.9％）至少有一次血清总睾酮测量。7个人被排除在这项研究之外，因为他们目前正在接受睾酮治疗，留下69个人的最终样本量用于分析。人口统计数据,血清睾酮浓度，和其他与低睾酮浓度相关的因素被收集。低睾酮定义为低于300ng/dL的值。回归分析用于确定与低睾酮水平相关的因素。
结果：69名符合条件的参与者的平均（±SD）年龄为33.34±10.98岁。平均睾酮浓度为421±158.5ng/dL，27.54%的男性睾酮值低于300ng/dL。平均血红蛋白水平为14.23±2.18g/dL。睾酮水平与血红蛋白水平呈正相关。测量时间和年龄与睾酮水平无关。
结论：在我们的样本中，大约有四分之一的CF男性表现出睾酮低。CF男性患者的低血红蛋白与低睾酮水平相关。一天中的时间和年龄都不影响该样品中的睾酮浓度。
方法：这项回顾性研究得到了埃默里大学机构审查委员会（IRB）的批准。数据是从Emory囊性纤维化中心接受治疗的CF成年男性的电子病历中提取的。从2016年到2023年，我们中心共跟踪了129名CF患者。在这些人中,76名CF男性（58.9％）至少有一次血清总睾酮测量。7个人被排除在这项研究之外，因为他们目前正在接受睾酮治疗，留下69个人的最终样本量用于分析。人口统计数据,血清睾酮浓度，和其他与低睾酮浓度相关的因素被收集。低睾酮定义为低于300ng/dL的值。回归分析用于确定与低睾酮水平相关的因素。
结果：69名符合条件的参与者的平均（±SD）年龄为33.34±10.98岁。平均睾酮浓度为421±158.5ng/dL，27.54%的男性睾酮值低于300ng/dL。平均血红蛋白水平为14.23±2.18g/dL。睾酮水平与血红蛋白水平呈正相关。测量时间和年龄与睾酮水平无关。
结论：在我们的样本中，大约有四分之一的CF男性表现出睾酮低。CF男性患者的低血红蛋白与低睾酮水平相关。一天中的时间和年龄都不影响该样品中的睾酮浓度。
