Abstract：
OBJECTIVE: Evidence is scarce regarding the association between anemia and alterations in cognitive level among hospitalized older patients. We aimed to evaluate the associations between baseline hemoglobin (Hb) levels and changes in cognitive level in patients undergoing rehabilitation after stroke.
METHODS: A retrospective cohort study was conducted, encompassing consecutively hospitalized post-stroke patients. Data on serum Hb levels were extracted from medical records, specifically tests conducted within 24 hours of admission. Primary outcomes included discharge scores for cognitive function assessed by the cognitive domain of the Functional Independence Measure (FIM-cognition) and the corresponding change in FIM-cognition during hospitalization. Another outcome measure was the length of hospital stay. Multivariate linear regression analyses were employed to assess the association between Hb levels at admission and the designated outcomes, adjusting for potential confounding factors.
RESULTS: Data from 955 patients (mean age 73.2 years; 53.6% men) were included in the analysis. The median Hb level at admission was 13.3 [11.9, 14.5] g/dL. After fully adjusting for confounding factors, the baseline Hb level was significantly and positively associated with FIM-cognition at discharge (β = 0.045, p = 0.025) and its gain (β = 0.073, p = 0.025). Further, the baseline Hb level was independently and negatively associated with length of hospital stay (β = -0.013, p = 0.026).
CONCLUSIONS: Elevated baseline Hb levels are correlated with preserved cognitive level and shorter hospital stays in post-stroke patients. Evaluating anemia at the outset serves as a crucial prognostic indicator.
METHODS: A retrospective cohort study was conducted, encompassing consecutively hospitalized post-stroke patients. Data on serum Hb levels were extracted from medical records, specifically tests conducted within 24 hours of admission. Primary outcomes included discharge scores for cognitive function assessed by the cognitive domain of the Functional Independence Measure (FIM-cognition) and the corresponding change in FIM-cognition during hospitalization. Another outcome measure was the length of hospital stay. Multivariate linear regression analyses were employed to assess the association between Hb levels at admission and the designated outcomes, adjusting for potential confounding factors.
RESULTS: Data from 955 patients (mean age 73.2 years; 53.6% men) were included in the analysis. The median Hb level at admission was 13.3 [11.9, 14.5] g/dL. After fully adjusting for confounding factors, the baseline Hb level was significantly and positively associated with FIM-cognition at discharge (β = 0.045, p = 0.025) and its gain (β = 0.073, p = 0.025). Further, the baseline Hb level was independently and negatively associated with length of hospital stay (β = -0.013, p = 0.026).
CONCLUSIONS: Elevated baseline Hb levels are correlated with preserved cognitive level and shorter hospital stays in post-stroke patients. Evaluating anemia at the outset serves as a crucial prognostic indicator.
摘要：
目的：关于住院老年患者贫血与认知水平改变之间的关联的证据很少。我们旨在评估卒中后康复患者的基线血红蛋白（Hb）水平与认知水平变化之间的关系。
方法：进行了一项回顾性队列研究，包括连续住院的卒中后患者。从医疗记录中提取血清Hb水平的数据，特别是在入院后24小时内进行的测试。主要结果包括通过功能独立性测量（FIM-cognition）的认知领域评估的认知功能的出院评分以及住院期间FIM认知的相应变化。另一个结果指标是住院时间。多元线性回归分析用于评估入院时Hb水平与指定结果之间的关联。调整潜在的混杂因素。
结果：955名患者（平均年龄73.2岁；53.6%男性）的数据被纳入分析。入院时Hb中位数为13.3[11.9,14.5]g/dL。在充分调整混杂因素后，基线Hb水平与出院时的FIM认知（β=0.045，p=0.025）和其增益（β=0.073，p=0.025）显着正相关。Further,基线Hb水平与住院时间呈独立负相关(β=-0.013,p=0.026).
结论：卒中后患者基线Hb水平升高与认知水平保持和住院时间缩短相关。在开始时评估贫血是至关重要的预后指标。
方法：进行了一项回顾性队列研究，包括连续住院的卒中后患者。从医疗记录中提取血清Hb水平的数据，特别是在入院后24小时内进行的测试。主要结果包括通过功能独立性测量（FIM-cognition）的认知领域评估的认知功能的出院评分以及住院期间FIM认知的相应变化。另一个结果指标是住院时间。多元线性回归分析用于评估入院时Hb水平与指定结果之间的关联。调整潜在的混杂因素。
结果：955名患者（平均年龄73.2岁；53.6%男性）的数据被纳入分析。入院时Hb中位数为13.3[11.9,14.5]g/dL。在充分调整混杂因素后，基线Hb水平与出院时的FIM认知（β=0.045，p=0.025）和其增益（β=0.073，p=0.025）显着正相关。Further,基线Hb水平与住院时间呈独立负相关(β=-0.013,p=0.026).
结论：卒中后患者基线Hb水平升高与认知水平保持和住院时间缩短相关。在开始时评估贫血是至关重要的预后指标。
