Abstract：
OBJECTIVE: Insulin resistance (IR) is a risk factor for several cardiometabolic disorders; however, there is conflicting evidence about the reliability of certain IR markers. In this context, the triglyceride-glucose index (TyG) has been proposed as a surrogate marker for IR. This study aimed to compare the TyG index and homeostasis model assessment of insulin resistance (HOMA-IR).
RESULTS: A cross-sectional analysis was conducted using baseline data from 11,314 adults (aged 35-74 years) from the ELSA-Brasil study. The correlation between TyG and HOMA-IR, their interrater reliability, and their predictive value in identifying metabolic syndrome (MetS) were assessed. The mean TyG and HOMA-IR in our sample were 8.81 ± 0.52 and 2.78 ± 1.58 for men, and 8.53 ± 0.48 and 2.49 ± 1.38 for women, respectively. TyG and HOMA-IR showed a weak to moderate correlation with each other (Pearson\'s r for men: 0.395 and 0.409 for women, p-value <0.05) and other markers of glycemic metabolism. Additionally, the area under the curve for the prediction of MetS was greater for TyG than HOMA-IR, regardless of sex (TyG: 0.836 for men and 0.826 for women; HOMA-IR: 0.775 for men and 0.787 for women). The concordance between these markers was low (Coheńs kappa coefficient: 0.307 for men and 0.306 for women). Individuals with increased TyG exhibited mainly anthropometrical and glycemic metabolic alterations, whereas those with elevated HOMA-IR displayed mostly lipid-associated metabolic alterations.
CONCLUSIONS: TyG and HOMA-IR might indicate different profiles of cardiometabolic disorders, showing poor agreement in classifying individuals (normal vs. altered) and a weak correlation. Therefore, further studies are needed to investigate the role of TyG as a surrogate marker of IR.
RESULTS: A cross-sectional analysis was conducted using baseline data from 11,314 adults (aged 35-74 years) from the ELSA-Brasil study. The correlation between TyG and HOMA-IR, their interrater reliability, and their predictive value in identifying metabolic syndrome (MetS) were assessed. The mean TyG and HOMA-IR in our sample were 8.81 ± 0.52 and 2.78 ± 1.58 for men, and 8.53 ± 0.48 and 2.49 ± 1.38 for women, respectively. TyG and HOMA-IR showed a weak to moderate correlation with each other (Pearson\'s r for men: 0.395 and 0.409 for women, p-value <0.05) and other markers of glycemic metabolism. Additionally, the area under the curve for the prediction of MetS was greater for TyG than HOMA-IR, regardless of sex (TyG: 0.836 for men and 0.826 for women; HOMA-IR: 0.775 for men and 0.787 for women). The concordance between these markers was low (Coheńs kappa coefficient: 0.307 for men and 0.306 for women). Individuals with increased TyG exhibited mainly anthropometrical and glycemic metabolic alterations, whereas those with elevated HOMA-IR displayed mostly lipid-associated metabolic alterations.
CONCLUSIONS: TyG and HOMA-IR might indicate different profiles of cardiometabolic disorders, showing poor agreement in classifying individuals (normal vs. altered) and a weak correlation. Therefore, further studies are needed to investigate the role of TyG as a surrogate marker of IR.
摘要：
目的：胰岛素抵抗（IR）是几种心脏代谢紊乱的危险因素；然而，关于某些IR标记的可靠性存在相互矛盾的证据。在这种情况下，甘油三酯-葡萄糖指数(TyG)已被提出作为IR的替代标记。本研究旨在比较TyG指数和稳态模型对胰岛素抵抗（HOMA-IR）的评估。
结果：使用来自ELSA-Brasil研究的11,314名成年人（35-74岁）的基线数据进行了横断面分析。TyG与HOMA-IR的相关性，他们的中间可靠性，并评估了其在识别代谢综合征（MetS）中的预测价值。在我们的样本中，男性的平均TyG和HOMA-IR分别为8.81±0.52和2.78±1.58，女性为8.53±0.48和2.49±1.38，分别。TyG和HOMA-IR显示出彼此之间的弱至中度相关性（男性的皮尔逊r：0.395和女性的0.409，p值<0.05)和其他血糖代谢标志物。此外,TyG预测MetS的曲线下面积大于HOMA-IR，不分性别（TyG：男性0.836，女性0.826；HOMA-IR：男性0.775，女性0.787）。这些标记之间的一致性很低（Coheñskappa系数：男性为0.307，女性为0.306）。TyG增加的个体主要表现为人体测量和血糖代谢改变，而HOMA-IR升高的患者大多表现出脂质相关的代谢改变。
结论：TyG和HOMA-IR可能表明心脏代谢紊乱的不同特征，在对个人进行分类时表现出较差的一致性(正常与改变)和弱相关性。因此,需要进一步的研究来研究TyG作为IR的替代标志物的作用。
结果：使用来自ELSA-Brasil研究的11,314名成年人（35-74岁）的基线数据进行了横断面分析。TyG与HOMA-IR的相关性，他们的中间可靠性，并评估了其在识别代谢综合征（MetS）中的预测价值。在我们的样本中，男性的平均TyG和HOMA-IR分别为8.81±0.52和2.78±1.58，女性为8.53±0.48和2.49±1.38，分别。TyG和HOMA-IR显示出彼此之间的弱至中度相关性（男性的皮尔逊r：0.395和女性的0.409，p值<0.05)和其他血糖代谢标志物。此外,TyG预测MetS的曲线下面积大于HOMA-IR，不分性别（TyG：男性0.836，女性0.826；HOMA-IR：男性0.775，女性0.787）。这些标记之间的一致性很低（Coheñskappa系数：男性为0.307，女性为0.306）。TyG增加的个体主要表现为人体测量和血糖代谢改变，而HOMA-IR升高的患者大多表现出脂质相关的代谢改变。
结论：TyG和HOMA-IR可能表明心脏代谢紊乱的不同特征，在对个人进行分类时表现出较差的一致性(正常与改变)和弱相关性。因此,需要进一步的研究来研究TyG作为IR的替代标志物的作用。
