Abstract：
OBJECTIVE: To report utilization, effectiveness, and safety of assisted reproductive technologies in 2015 and 2016.
METHODS: Retrospective, cross-sectional survey of 3103 assisted reproductive technology clinics in 74 countries in 2015 and 3249 clinics in 79 countries in 2016 that submitted cycle and pregnancy outcome data through national and regional registries.
METHODS: Patients undergoing assisted reproductive technology procedures.
METHODS: Assisted reproductive technology.
METHODS: Outcomes on country, regional, and global levels.
RESULTS: Reported for 2015: 2,358,239 cycles with 548,652 babies born; for 2016: 2,807,963 cycles with 647,188 babies born. Estimated in 2015, ≥2,683,677 cycles resulted in >675,134 babies; in 2016, ≥3,100,448 cycles resulted in ≥723,026 babies. Reported cycles represent approximately 80% of global utilization. In 2015 and 2016, 27.6% and 27.8%, respectively, of women undergoing fresh autologous cycles were age ≥40 years. Frozen-thawed embryo transfer cycles accounted for 47.0% and 51.9%, respectively, of all embryo transfers in 2015 and 2016. Oocyte donation cycles accounted for 6.7% and 7.1% of all embryo transfers in 2015 and 2016. Intracytoplasmic sperm injection was performed in 57.7% and 56.4% of autologous aspiration cycles in 2015 and 2016, respectively. The cumulative delivery rate per aspiration cycle for fresh and frozen-thawed embryo transfer was 32.4% in 2015 and 33.1% in 2016, respectively. The average number of transferred embryos was 1.70 in 2015 and 1.69 in 2016. The proportion of single embryo transfers in fresh autologous cycles increased from 42.1% in 2015 to 44.0% in 2016. The twin delivery rate decreased from 16.0% in 2015 to 14.7% in 2016, and the triplet rate decreased from 0.6% in 2015 to 0.4% in 2016. The proportion of single embryo transfers in frozen-thawed embryo transfer autologous cycles was 62.2% in 2015 and 64.2% in 2016, with twin and triplet rates of 10.1% and 0.3% in 2015 and 10.0% and 0.2% in 2016, respectively.
CONCLUSIONS: Utilization of assisted reproductive technology and births per cycle increased from 2015 to 2016 while multiple births were reduced . Increasing proportion of frozen-thawed embryo transfer cycles, continuing wide variation in use of intracytoplasmic sperm injection, and increase in single embryo transfer rates are reported.
METHODS: Retrospective, cross-sectional survey of 3103 assisted reproductive technology clinics in 74 countries in 2015 and 3249 clinics in 79 countries in 2016 that submitted cycle and pregnancy outcome data through national and regional registries.
METHODS: Patients undergoing assisted reproductive technology procedures.
METHODS: Assisted reproductive technology.
METHODS: Outcomes on country, regional, and global levels.
RESULTS: Reported for 2015: 2,358,239 cycles with 548,652 babies born; for 2016: 2,807,963 cycles with 647,188 babies born. Estimated in 2015, ≥2,683,677 cycles resulted in >675,134 babies; in 2016, ≥3,100,448 cycles resulted in ≥723,026 babies. Reported cycles represent approximately 80% of global utilization. In 2015 and 2016, 27.6% and 27.8%, respectively, of women undergoing fresh autologous cycles were age ≥40 years. Frozen-thawed embryo transfer cycles accounted for 47.0% and 51.9%, respectively, of all embryo transfers in 2015 and 2016. Oocyte donation cycles accounted for 6.7% and 7.1% of all embryo transfers in 2015 and 2016. Intracytoplasmic sperm injection was performed in 57.7% and 56.4% of autologous aspiration cycles in 2015 and 2016, respectively. The cumulative delivery rate per aspiration cycle for fresh and frozen-thawed embryo transfer was 32.4% in 2015 and 33.1% in 2016, respectively. The average number of transferred embryos was 1.70 in 2015 and 1.69 in 2016. The proportion of single embryo transfers in fresh autologous cycles increased from 42.1% in 2015 to 44.0% in 2016. The twin delivery rate decreased from 16.0% in 2015 to 14.7% in 2016, and the triplet rate decreased from 0.6% in 2015 to 0.4% in 2016. The proportion of single embryo transfers in frozen-thawed embryo transfer autologous cycles was 62.2% in 2015 and 64.2% in 2016, with twin and triplet rates of 10.1% and 0.3% in 2015 and 10.0% and 0.2% in 2016, respectively.
CONCLUSIONS: Utilization of assisted reproductive technology and births per cycle increased from 2015 to 2016 while multiple births were reduced . Increasing proportion of frozen-thawed embryo transfer cycles, continuing wide variation in use of intracytoplasmic sperm injection, and increase in single embryo transfer rates are reported.
摘要：
目的：报告利用率，有效性,2015年和2016年辅助生殖技术的安全性。
方法：回顾性，2015年对74个国家的3103个辅助生殖技术诊所和2016年79个国家的3249个诊所进行横断面调查,通过国家和地区登记册提交周期和妊娠结局数据.
方法：接受辅助生殖技术程序的患者。
方法：辅助生殖技术。
方法：关于国家/地区的结果，区域,和全球层面。
结果：2015年报告：2,358,239个周期，548,652名婴儿出生；2016年：2,807,963个周期，647,188名婴儿出生。估计在2015年，≥2,683,677个周期导致>675,134个婴儿;在2016年，≥3,100,448个周期导致≥723,026个婴儿。报告的周期约占全球利用率的80％。2015年和2016年分别为27.6%和27.8%，分别,接受新鲜自体周期的女性年龄≥40岁.冻融胚胎移植周期分别占47.0%和51.9%,分别,在2015年和2016年的所有胚胎移植中。2015年和2016年，卵母细胞捐赠周期占所有胚胎移植的6.7%和7.1%。2015年和2016年，卵胞浆内单精子注射分别占自体抽吸周期的57.7%和56.4%。新鲜和冻融胚胎移植每个抽吸周期的累积分娩率在2015年和2016年分别为32.4％和33.1％。2015年移植胚胎的平均数量为1.70，2016年为1.69。新鲜自体周期中单个胚胎移植的比例从2015年的42.1%增加到2016年的44.0%。双胞胎分娩率从2015年的16.0%下降到2016年的14.7%，三胞胎分娩率从2015年的0.6%下降到2016年的0.4%。2015年冻融胚胎移植自体周期中单胚胎移植的比例为62.2%，2016年为64.2%，2015年双胎和三胎率分别为10.1%和0.3%，2016年为10.0%和0.2%。
结论：从2015年到2016年，辅助生殖技术的利用和每个周期的出生增加，而多胎减少。冻融胚胎移植周期的比例增加，胞浆内单精子注射的使用持续广泛变化，据报道，单胚胎移植率增加。
方法：回顾性，2015年对74个国家的3103个辅助生殖技术诊所和2016年79个国家的3249个诊所进行横断面调查,通过国家和地区登记册提交周期和妊娠结局数据.
方法：接受辅助生殖技术程序的患者。
方法：辅助生殖技术。
方法：关于国家/地区的结果，区域,和全球层面。
结果：2015年报告：2,358,239个周期，548,652名婴儿出生；2016年：2,807,963个周期，647,188名婴儿出生。估计在2015年，≥2,683,677个周期导致>675,134个婴儿;在2016年，≥3,100,448个周期导致≥723,026个婴儿。报告的周期约占全球利用率的80％。2015年和2016年分别为27.6%和27.8%，分别,接受新鲜自体周期的女性年龄≥40岁.冻融胚胎移植周期分别占47.0%和51.9%,分别,在2015年和2016年的所有胚胎移植中。2015年和2016年，卵母细胞捐赠周期占所有胚胎移植的6.7%和7.1%。2015年和2016年，卵胞浆内单精子注射分别占自体抽吸周期的57.7%和56.4%。新鲜和冻融胚胎移植每个抽吸周期的累积分娩率在2015年和2016年分别为32.4％和33.1％。2015年移植胚胎的平均数量为1.70，2016年为1.69。新鲜自体周期中单个胚胎移植的比例从2015年的42.1%增加到2016年的44.0%。双胞胎分娩率从2015年的16.0%下降到2016年的14.7%，三胞胎分娩率从2015年的0.6%下降到2016年的0.4%。2015年冻融胚胎移植自体周期中单胚胎移植的比例为62.2%，2016年为64.2%，2015年双胎和三胎率分别为10.1%和0.3%，2016年为10.0%和0.2%。
结论：从2015年到2016年，辅助生殖技术的利用和每个周期的出生增加，而多胎减少。冻融胚胎移植周期的比例增加，胞浆内单精子注射的使用持续广泛变化，据报道，单胚胎移植率增加。
