METHODS: The study included 118 COPD patients admitted to Changxing People\'s Hospital between July 2020 and July 2023. All patients received a 1.5 T MRI of the brain and pulmonary function tests. A cognitive function assessment was conducted via the Montreal Cognitive Assessment (MoCA) scale, and patients were divided into two groups. The relationship between the MoCA and CSVD burden score was analyzed by Pearson correlation, and to identify risk factors, multiple logistic regression analysis was performed.
RESULTS: The study showed a negative correlation between the MoCA and CSVD burden score in COPD patients (r=-0.479, P<0.001). Multiple logistic regression analysis found that age (OR=2.264, 95 % CI: 1.426-3.596, P<0.001), COPD grade (OR=3.139, 95 % CI: 2.012-4.898, P<0.001), as well as CSVD burden score (OR=5.336, 95 % CI: 1.191-23.900, P<0.001) were the independent risk factors for CI in COPD patients (P<0.05).
CONCLUSIONS: When screening for cognitive impairment in COPD patients, the CSVD burden score can be used in conjunction with cognitive assessment scales to make judgments.
方法:本研究纳入了2020年7月至2023年7月长兴人民医院收治的118例COPD患者。所有患者均接受1.5T脑MRI和肺功能检查。通过蒙特利尔认知评估(MoCA)量表进行认知功能评估,并将患者分为两组。采用Pearson相关性分析MoCA与CSVD负担评分的关系,并确定风险因素,进行多因素logistic回归分析.
结果:研究显示COPD患者MoCA与CSVD负荷评分呈负相关(r=-0.479,P<0.001)。多因素Logistic回归分析发现年龄(OR=2.264,95%CI:1.426~3.596,P<0.001),COPD分级(OR=3.139,95%CI:2.012-4.898,P<0.001),CSVD负担评分(OR=5.336,95%CI:1.191~23.900,P<0.001)是COPD患者发生CI的独立危险因素(P<0.05)。
结论:在筛查COPD患者的认知障碍时,CSVD负担评分可与认知评估量表结合使用以做出判断.