Abstract：
OBJECTIVE: The function of choroid plexus is to produce cerebrospinal fluid, which is critical for the glymphatic system function. In this study, we aimed to analyze the differences in choroid plexus volume between patients with obstructive sleep apnea (OSA) and healthy controls, with the goal of discovering the glymphatic system dysfunction in patients with OSA.
METHODS: We prospectively enrolled 40 patients with OSA confirmed by polysomnography and 38 age- and sex-matched healthy controls. All participants underwent three-dimensional T1-weighted brain imaging, which was suitable for volumetric analysis. We compared choroid plexus volumes between patients with OSA and healthy controls, and analyzed the association between choroid plexus volume and polysomnographic findings in patients with OSA.
RESULTS: Choroid plexus volumes were significantly larger in patients with OSA than in healthy controls (2.311 % vs. 2.096 %, p = 0.005). However, no significant association was detected between choroid plexus volume and polysomnographic findings.
CONCLUSIONS: This study demonstrated enlargement of the choroid plexus in patients with OSA compared with healthy controls. This finding could be related with glymphatic system dysfunction in patients with OSA.
METHODS: We prospectively enrolled 40 patients with OSA confirmed by polysomnography and 38 age- and sex-matched healthy controls. All participants underwent three-dimensional T1-weighted brain imaging, which was suitable for volumetric analysis. We compared choroid plexus volumes between patients with OSA and healthy controls, and analyzed the association between choroid plexus volume and polysomnographic findings in patients with OSA.
RESULTS: Choroid plexus volumes were significantly larger in patients with OSA than in healthy controls (2.311 % vs. 2.096 %, p = 0.005). However, no significant association was detected between choroid plexus volume and polysomnographic findings.
CONCLUSIONS: This study demonstrated enlargement of the choroid plexus in patients with OSA compared with healthy controls. This finding could be related with glymphatic system dysfunction in patients with OSA.
摘要：
目的：脉络丛的功能是产生脑脊液，这对淋巴系统的功能至关重要。在这项研究中,我们旨在分析阻塞性睡眠呼吸暂停（OSA）患者与健康对照组之间脉络丛体积的差异，目的是发现OSA患者的淋巴系统功能障碍。
方法：我们前瞻性招募了40例多导睡眠图确诊的OSA患者和38例年龄和性别匹配的健康对照。所有参与者都接受了三维T1加权脑成像，适用于体积分析。我们比较了OSA患者和健康对照组之间的脉络丛体积，并分析了OSA患者脉络丛体积与多导睡眠图表现之间的关系。
结果：OSA患者的脉络丛体积明显大于健康对照组（2.311%vs.2.096%,p=0.005)。然而,在脉络丛体积和多导睡眠检查结果之间未检测到显著关联.
结论：本研究显示，与健康对照组相比，OSA患者的脉络丛增大。这一发现可能与OSA患者的淋巴系统功能障碍有关。
方法：我们前瞻性招募了40例多导睡眠图确诊的OSA患者和38例年龄和性别匹配的健康对照。所有参与者都接受了三维T1加权脑成像，适用于体积分析。我们比较了OSA患者和健康对照组之间的脉络丛体积，并分析了OSA患者脉络丛体积与多导睡眠图表现之间的关系。
结果：OSA患者的脉络丛体积明显大于健康对照组（2.311%vs.2.096%,p=0.005)。然而,在脉络丛体积和多导睡眠检查结果之间未检测到显著关联.
结论：本研究显示，与健康对照组相比，OSA患者的脉络丛增大。这一发现可能与OSA患者的淋巴系统功能障碍有关。
