Abstract：
BACKGROUND: Turbo spin-echo (TSE) diffusion-weighted imaging (DWI) sequences may reduce susceptibility artifacts and image distortion in sellar region, allowing better visualization of small pituitary lesions, and may be used to assist in the diagnosis of pituitary microadenomas.
OBJECTIVE: To explore the application value of conventional MRI combined with DWI sequences in the diagnosis of microprolactinomas.
METHODS: Prospective.
METHODS: Thirty-four patients in microprolactinomas with high signal on T2WI (HT2-PRL) group (34 females, 34 ± 7 years), 26 patients in microprolactinomas with equal or low signal on T2WI (ELT2-PRL) group (21 females, 34 ± 7 years), 35 patients with hyperprolactinemia (33 females, 32 ± 8 years), and 30 normal controls (25 females, 31 ± 7 years).
UNASSIGNED: TSE sequence at 3 T.
RESULTS: Pituitary morphological parameters (such as length and volume), dynamic contrast-enhanced parameters (such as time to peak) and the apparent diffusion coefficients (ADCs) were measured in each group.
METHODS: ANOVA and Mann-Whitney U test were used to compare parameters among groups. Spearman\'s coefficient was used to evaluate the correlation between variables. ROC analysis was used to assess the performance of the parameters. A P-value <0.05 was considered statistically significant.
RESULTS: The pituitary volume of patients in HT2-PRL, ELT2-PRL, and hyperprolactinemia group were 831.00 (747.60, 887.60), 923.63 ± 219.34, and 737.20 (606.40, 836.80) mm3. The pituitary maximum height in these three groups were 7.03 (6.43, 8.63), 8.03 ± 1.41, and 6.63 ± 1.28 mm, respectively. The lesion ADC value was significantly correlated with T2 relative signal intensity (the ratio of signal intensity of microprolactinoma or anterior pituitary to left temporal cortex) (r = 0.821). Compared with patients with hyperprolactinemia, the diagnostic efficacy of T2 relative signal intensity was higher in HT2-PRL group, with an AUC of 0.954, whereas the ADC value was the highest in ELT2-PRL group, with an AUC of 0.924.
CONCLUSIONS: DWI sequences can be used to assist in the diagnosis of pituitary microadenomas.
METHODS: 1 TECHNICAL EFFICACY: Stage 2.
OBJECTIVE: To explore the application value of conventional MRI combined with DWI sequences in the diagnosis of microprolactinomas.
METHODS: Prospective.
METHODS: Thirty-four patients in microprolactinomas with high signal on T2WI (HT2-PRL) group (34 females, 34 ± 7 years), 26 patients in microprolactinomas with equal or low signal on T2WI (ELT2-PRL) group (21 females, 34 ± 7 years), 35 patients with hyperprolactinemia (33 females, 32 ± 8 years), and 30 normal controls (25 females, 31 ± 7 years).
UNASSIGNED: TSE sequence at 3 T.
RESULTS: Pituitary morphological parameters (such as length and volume), dynamic contrast-enhanced parameters (such as time to peak) and the apparent diffusion coefficients (ADCs) were measured in each group.
METHODS: ANOVA and Mann-Whitney U test were used to compare parameters among groups. Spearman\'s coefficient was used to evaluate the correlation between variables. ROC analysis was used to assess the performance of the parameters. A P-value <0.05 was considered statistically significant.
RESULTS: The pituitary volume of patients in HT2-PRL, ELT2-PRL, and hyperprolactinemia group were 831.00 (747.60, 887.60), 923.63 ± 219.34, and 737.20 (606.40, 836.80) mm3. The pituitary maximum height in these three groups were 7.03 (6.43, 8.63), 8.03 ± 1.41, and 6.63 ± 1.28 mm, respectively. The lesion ADC value was significantly correlated with T2 relative signal intensity (the ratio of signal intensity of microprolactinoma or anterior pituitary to left temporal cortex) (r = 0.821). Compared with patients with hyperprolactinemia, the diagnostic efficacy of T2 relative signal intensity was higher in HT2-PRL group, with an AUC of 0.954, whereas the ADC value was the highest in ELT2-PRL group, with an AUC of 0.924.
CONCLUSIONS: DWI sequences can be used to assist in the diagnosis of pituitary microadenomas.
METHODS: 1 TECHNICAL EFFICACY: Stage 2.
摘要：
背景：涡轮自旋回波（TSE）扩散加权成像（DWI）序列可以减少鞍区的磁化率伪影和图像失真，可以更好地观察垂体小病变，并可用于辅助诊断垂体微腺瘤。
目的：探讨常规MRI结合DWI序列在微泌乳素腺瘤诊断中的应用价值。
方法：前瞻性。
方法：T2WI（HT2-PRL）组34例微泌乳素瘤高信号患者（34例女性，34±7年），T2WI（ELT2-PRL）组中信号相等或低的微泌乳素瘤患者26例（女性21例，34±7年），35例高泌乳素血症（33例女性，32±8年），和30名正常对照(25名女性，31±7年）。
■3T处的TSE序列
结果：垂体形态学参数（例如长度和体积），测量各组动态对比增强参数(如达峰时间)和表观扩散系数(ADC).
方法：采用方差分析和Mann-WhitneyU检验比较各组参数。采用Spearman系数评价变量之间的相关性。ROC分析用于评估参数的性能。P值<0.05被认为具有统计学意义。
结果：HT2-PRL患者的垂体体积，ELT2-PRL,高泌乳素血症组为831.00(747.60,887.60),923.63±219.34和737.20(606.40,836.80)mm3。三组的最大垂体高度分别为7.03(6.43,8.63),8.03±1.41,6.63±1.28mm,分别。病变ADC值与T2相对信号强度（微泌乳素瘤或垂体前叶与左颞叶皮质的信号强度之比）显着相关（r=0.821）。与高泌乳素血症患者相比，T2相对信号强度在HT2-PRL组中的诊断效能更高，AUC为0.954，而ELT2-PRL组的ADC值最高，AUC为0.924。
结论：DWI序列可用于垂体微腺瘤的辅助诊断。
方法：1技术效果：阶段2。
目的：探讨常规MRI结合DWI序列在微泌乳素腺瘤诊断中的应用价值。
方法：前瞻性。
方法：T2WI（HT2-PRL）组34例微泌乳素瘤高信号患者（34例女性，34±7年），T2WI（ELT2-PRL）组中信号相等或低的微泌乳素瘤患者26例（女性21例，34±7年），35例高泌乳素血症（33例女性，32±8年），和30名正常对照(25名女性，31±7年）。
■3T处的TSE序列
结果：垂体形态学参数（例如长度和体积），测量各组动态对比增强参数(如达峰时间)和表观扩散系数(ADC).
方法：采用方差分析和Mann-WhitneyU检验比较各组参数。采用Spearman系数评价变量之间的相关性。ROC分析用于评估参数的性能。P值<0.05被认为具有统计学意义。
结果：HT2-PRL患者的垂体体积，ELT2-PRL,高泌乳素血症组为831.00(747.60,887.60),923.63±219.34和737.20(606.40,836.80)mm3。三组的最大垂体高度分别为7.03(6.43,8.63),8.03±1.41,6.63±1.28mm,分别。病变ADC值与T2相对信号强度（微泌乳素瘤或垂体前叶与左颞叶皮质的信号强度之比）显着相关（r=0.821）。与高泌乳素血症患者相比，T2相对信号强度在HT2-PRL组中的诊断效能更高，AUC为0.954，而ELT2-PRL组的ADC值最高，AUC为0.924。
结论：DWI序列可用于垂体微腺瘤的辅助诊断。
方法：1技术效果：阶段2。
