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Abstract：
BACKGROUND: This study aimed to explore the potential influence of kisspeptin (KISS1) levels on the etiology of placenta previa for early pregnancy diagnosis.
METHODS: The study included 20 pregnant women diagnosed with placenta previa and 20 pregnant woman with normal pregnancies between 2021 and 2022. Plasma KISS1 levels were determined through biochemical analysis, while genetic analysis assessed KISS1 and KISS1 receptor gene expression levels. Immunohistochemical methods were employed to determine placenta KISS1 levels.
RESULTS: The evaluation of KISS1 concentration in serum revealed a significant decrease in the placenta previa group compared to the control group (P < .001). KISS1 gene expression level 0.043-fold decreased in the placenta previa group (P < .001). Furthermore, the KISS1 receptor gene expression level increased 170-fold in the placenta previa group.
CONCLUSIONS: Results from biochemical, immunohistochemical, and genetic analyses consistently indicated significantly reduced KISS1 expression in patients with placenta previa. These findings suggest a potential link between diminished KISS1 levels and the occurrence of placenta previa. KISS1 may play a critical role in the etiology of placenta previa. Detailed studies on angiogenesis, cell migration and tissue modeling should be conducted to understand possible mechanisms.
METHODS: The study included 20 pregnant women diagnosed with placenta previa and 20 pregnant woman with normal pregnancies between 2021 and 2022. Plasma KISS1 levels were determined through biochemical analysis, while genetic analysis assessed KISS1 and KISS1 receptor gene expression levels. Immunohistochemical methods were employed to determine placenta KISS1 levels.
RESULTS: The evaluation of KISS1 concentration in serum revealed a significant decrease in the placenta previa group compared to the control group (P < .001). KISS1 gene expression level 0.043-fold decreased in the placenta previa group (P < .001). Furthermore, the KISS1 receptor gene expression level increased 170-fold in the placenta previa group.
CONCLUSIONS: Results from biochemical, immunohistochemical, and genetic analyses consistently indicated significantly reduced KISS1 expression in patients with placenta previa. These findings suggest a potential link between diminished KISS1 levels and the occurrence of placenta previa. KISS1 may play a critical role in the etiology of placenta previa. Detailed studies on angiogenesis, cell migration and tissue modeling should be conducted to understand possible mechanisms.
摘要：
背景：本研究旨在探讨kisspeptin（KISS1）水平对前置胎盘病因的潜在影响，用于早期妊娠诊断。
方法：该研究包括20名被诊断为前置胎盘的孕妇和20名在2021年至2022年间正常妊娠的孕妇。通过生化分析测定血浆KISS1水平，而遗传分析评估KISS1和KISS1受体基因表达水平。采用免疫组织化学方法测定胎盘KISS1水平。
结果：血清中KISS1浓度的评估显示，与对照组相比，前置胎盘组明显降低（P<0.001）。前置胎盘组KISS1基因表达水平下降0.043倍(P<.001)。此外，在前置胎盘组中,KISS1受体基因表达水平增加了170倍.
结论：生化结果，免疫组织化学，遗传分析一致表明，前置胎盘患者的KISS1表达显着降低。这些发现表明KISS1水平降低与前置胎盘的发生之间存在潜在联系。KISS1可能在前置胎盘的病因中起关键作用。血管生成的详细研究，应进行细胞迁移和组织建模以了解可能的机制。
方法：该研究包括20名被诊断为前置胎盘的孕妇和20名在2021年至2022年间正常妊娠的孕妇。通过生化分析测定血浆KISS1水平，而遗传分析评估KISS1和KISS1受体基因表达水平。采用免疫组织化学方法测定胎盘KISS1水平。
结果：血清中KISS1浓度的评估显示，与对照组相比，前置胎盘组明显降低（P<0.001）。前置胎盘组KISS1基因表达水平下降0.043倍(P<.001)。此外，在前置胎盘组中,KISS1受体基因表达水平增加了170倍.
结论：生化结果，免疫组织化学，遗传分析一致表明，前置胎盘患者的KISS1表达显着降低。这些发现表明KISS1水平降低与前置胎盘的发生之间存在潜在联系。KISS1可能在前置胎盘的病因中起关键作用。血管生成的详细研究，应进行细胞迁移和组织建模以了解可能的机制。
