PDF(Pubmed)
Abstract：
BACKGROUND: Patients with bone metastasis-associated cancer pain often experience a complex mix of pain types. Consequently, the use of multimodal combination therapy is essential. While monitoring for common adverse reactions in pain treatment, it is also crucial to be vigilant for the rare but serious serotonin syndrome.
METHODS: A 53-year-old female with metastatic gastric cancer was hospitalized due to severe, uncontrolled thoracic and cervical pain. During the titration of her cancer pain medication, she developed serotonin syndrome.
METHODS: He was diagnosed with refractory cancer pain and serotonin syndrome.
METHODS: The complete process of cancer pain medication in a patient with gastric cancer and bone metastasis was analyzed, with a primary focus on the selection of analgesic medications, adjustment of opioid dosages, and prevention and treatment of medication-associated adverse reactions.
RESULTS: The patient\'s cancer pain was well controlled, with the prompt management of adverse reactions. Furthermore, by adjusting the medication regimen, intolerable adverse reactions were prevented.
CONCLUSIONS: In clinical settings, personalized analgesic regimens must be developed for patients with cancer pain to enhance patient compliance with medication, prevent the occurrence of severe adverse reactions, and improve the overall quality of life of patients with cancer. Healthcare professionals should pay increased attention to ADRs associated with opioid medications, whereas pharmacists should assist them in promptly identifying ADRs.
METHODS: A 53-year-old female with metastatic gastric cancer was hospitalized due to severe, uncontrolled thoracic and cervical pain. During the titration of her cancer pain medication, she developed serotonin syndrome.
METHODS: He was diagnosed with refractory cancer pain and serotonin syndrome.
METHODS: The complete process of cancer pain medication in a patient with gastric cancer and bone metastasis was analyzed, with a primary focus on the selection of analgesic medications, adjustment of opioid dosages, and prevention and treatment of medication-associated adverse reactions.
RESULTS: The patient\'s cancer pain was well controlled, with the prompt management of adverse reactions. Furthermore, by adjusting the medication regimen, intolerable adverse reactions were prevented.
CONCLUSIONS: In clinical settings, personalized analgesic regimens must be developed for patients with cancer pain to enhance patient compliance with medication, prevent the occurrence of severe adverse reactions, and improve the overall quality of life of patients with cancer. Healthcare professionals should pay increased attention to ADRs associated with opioid medications, whereas pharmacists should assist them in promptly identifying ADRs.
摘要：
背景：骨转移相关癌痛患者通常会经历复杂的疼痛类型组合。因此,多模式联合治疗的使用至关重要.在监测疼痛治疗中常见不良反应的同时，对罕见但严重的5-羟色胺综合征保持警惕也至关重要。
方法：一名53岁女性转移性胃癌因严重，不受控制的胸部和颈部疼痛。在她的癌症止痛药的滴定过程中，她患上了5-羟色胺综合症.
方法：他被诊断为难治性癌痛和5-羟色胺综合征。
方法：分析一例胃癌骨转移患者癌痛药物治疗的全过程，主要关注镇痛药物的选择，阿片类药物剂量的调整，以及药物相关不良反应的预防和治疗。
结果：患者的癌痛得到了很好的控制，随着不良反应的迅速管理。此外，通过调整用药方案，无法耐受的不良反应得以预防。
结论：在临床环境中，必须为癌症疼痛患者制定个性化的镇痛方案，以提高患者对药物的依从性，防止严重不良反应的发生，提高癌症患者的整体生活质量。医疗保健专业人员应更加关注与阿片类药物相关的ADR，而药剂师应该帮助他们及时识别ADR。
方法：一名53岁女性转移性胃癌因严重，不受控制的胸部和颈部疼痛。在她的癌症止痛药的滴定过程中，她患上了5-羟色胺综合症.
方法：他被诊断为难治性癌痛和5-羟色胺综合征。
方法：分析一例胃癌骨转移患者癌痛药物治疗的全过程，主要关注镇痛药物的选择，阿片类药物剂量的调整，以及药物相关不良反应的预防和治疗。
结果：患者的癌痛得到了很好的控制，随着不良反应的迅速管理。此外，通过调整用药方案，无法耐受的不良反应得以预防。
结论：在临床环境中，必须为癌症疼痛患者制定个性化的镇痛方案，以提高患者对药物的依从性，防止严重不良反应的发生，提高癌症患者的整体生活质量。医疗保健专业人员应更加关注与阿片类药物相关的ADR，而药剂师应该帮助他们及时识别ADR。
