Abstract：
There has been a significant increase in the incidence of multiple neurodegenerative and terminal diseases in the human population with life expectancy increasing in the current times. This highlights the urgent need for a more comprehensive understanding of how different aspects of lifestyle, in particular diet, may affect neural functioning and consequently cognitive performance as well as in enhancing overall health. Flavonoids, found in a variety of fruits, vegetables, and derived beverages, provide a new avenue of research that shows a promising influence on different aspects of brain function. However, despite the promising evidence, most bioactive compounds lack strong clinical research efficacy. In the current scoping review, we highlight the effects of Flavonoids on cognition and neural plasticity across vertebrates and invertebrates with special emphasis on the studies conducted in the pond snail, Lymnaea stagnalis, which has emerged to be a functionally dynamic model for studies on learning and memory. In conclusion, we suggest future research directions and discuss the social, cultural, and ethnic dependencies of bioactive compounds that influence how these compounds are used and accepted globally. Bridging the gap between preclinical and clinical studies about the effects of bioactive natural compounds on brain health will surely lead to lifestyle choices such as dietary Flavonoids being used complementarily rather than as replacements to classical drugs bringing about a healthier future.
摘要：
目前，随着预期寿命的增加，人类人群中多种神经退行性疾病和终末期疾病的发病率显着增加。这凸显了迫切需要更全面地了解生活方式的不同方面，特别是饮食，可能会影响神经功能，从而影响认知表现以及增强整体健康。黄酮类化合物,在各种水果中发现，蔬菜,和衍生的饮料，提供了一种新的研究途径，表明对大脑功能的不同方面有希望的影响。然而,尽管有很有希望的证据,大多数生物活性化合物缺乏较强的临床研究功效。在当前的范围审查中，我们强调了黄酮类化合物对脊椎动物和无脊椎动物的认知和神经可塑性的影响，特别强调了在池塘蜗牛中进行的研究，Lymnaeastagnalis,它已经成为学习和记忆研究的功能动态模型。总之,我们提出了未来的研究方向，并讨论了社会，文化,以及影响这些化合物在全球范围内使用和接受的生物活性化合物的种族依赖性。弥合关于生物活性天然化合物对大脑健康的影响的临床前和临床研究之间的差距，肯定会导致生活方式的选择，如饮食类黄酮被互补使用，而不是作为经典药物的替代品，带来更健康的未来。
