Abstract：
Alzheimer\'s disease (AD) research has been dominated by the single-factor amyloid hypothesis in the last decades. Several other hypotheses have been proposed and increasingly attract attention considering the limited success of amyloid-based therapeutic strategies. Surprisingly, most published alternative etiological hypotheses for AD are similarly single-factor hypotheses, such as vascular, metabolic, mitochondrial, infectious, and inflammatory hypotheses, but the existence of so many different hypotheses suggests that AD is most likely a complex, multifactorial disorder. This inventory of different etiological hypotheses will hopefully help the field to move forward with explanatory models that consider the multifaceted aspects of this devastating disorder.
摘要：
近几十年来,阿尔茨海默病(AD)的研究一直以单因子淀粉样蛋白假说为主导。考虑到基于淀粉样蛋白的治疗策略的有限成功，已经提出了其他几种假设并越来越引起人们的注意。令人惊讶的是,大多数已发表的AD替代病因假设都是类似的单因素假设，如血管，新陈代谢，线粒体，传染性,和炎症假设，但是许多不同的假设的存在表明AD很可能是一个复杂的，多因素障碍。这种不同病因假设的清单有望帮助该领域向前发展，并考虑了这种破坏性疾病的多方面方面的解释性模型。
