Abstract：
End-stage renal disease (ESRD) patients are considered immunocompromised, putting them at high risk for infections, including cytomegalovirus (CMV). CMV can affect hematological parameters, causing further complications in ESRD patients. This study intended to determine the seropositivity of CMV infection in hemodialysis patients and its effect on different blood parameters in ESRD patients to help decrease the overall dialysis associated morbidity and mortality. Blood samples were collected from 45 ESRD patients and 45 controls. A complete blood count was performed using an automated cell counter. CMV-specific IgM and IgG levels were measured using immunochemistry testing. The seropositivity for CMV-IgG was 42.2% in ESRD patients which was significantly higher than in control group (22.2%) (p=0.042). The seropositivity for CMV-IgM was 6.7% in ESRD patients with no difference with the control group (4.4%). The prevalence of anemia was significantly higher in CMV seropositive (77.3%) compared to CMV seronegative (47.8%) ESRD patients. Other studied blood parameters were not different between CMV seronegative and seropositive ESRD patients. In conclusion, CMV infection is a significant concern for dialysis patients and can affect hematological parameters, leading to further complications. Early detection and treatment of CMV infection and monitoring of CMV IgM and IgG levels are critical to prevent further complications and improve clinical outcomes.
摘要：
终末期肾病（ESRD）患者被认为是免疫功能低下，使他们面临感染的高风险，包括巨细胞病毒（CMV）。CMV可以影响血液学参数，在ESRD患者中引起进一步的并发症。这项研究旨在确定血液透析患者CMV感染的血清阳性率及其对ESRD患者不同血液参数的影响，以帮助降低总体透析相关的发病率和死亡率。从45名ESRD患者和45名对照收集血液样品。使用自动细胞计数器进行全血细胞计数。使用免疫化学测试测量CMV特异性IgM和IgG水平。ESRD患者的CMV-IgG血清阳性率为42.2％，显着高于对照组（22.2％）（p=0.042）。ESRD患者CMV-IgM的血清阳性率为6.7％，与对照组（4.4％）无差异。CMV血清阳性（77.3％）的贫血患病率明显高于CMV血清阴性（47.8％）的ESRD患者。其他研究的血液参数在CMV血清阴性和血清阳性ESRD患者之间没有差异。总之,CMV感染是透析患者的重要问题，可影响血液学参数，导致进一步的并发症。CMV感染的早期检测和治疗以及CMVIgM和IgG水平的监测对于防止进一步的并发症和改善临床结果至关重要。
