Abstract：
Neuropathic pain may be present in a proportion of patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Its presence may lead to the requirement of altered management approaches in these conditions. This study investigated the prevalence of neuropathic pain in OA as compared to that in RA. Patients with OA and RA were included cross-sectionally if they had no other known neuropathic disorder. The PainDETECT questionnaire was used to assess neuropathic pain. WOMAC and CDAI scores were used to assess disease severity in OA and RA respectively. 69 patients with OA with a mean WOMAC score of 53.30 ± 16.39 and 98 patients with RA with a mean CDAI of 25.48 ± 16.99 were compared. The median PainDETECT score for OA was 13 (0-30) and RA was 5 (0-37) [p<0.001]. 15 patients with OA and six patients with RA were highly likely to have neuropathic pain, while 15 patients with OA and 30 patients with RA were classified as possibly having neuropathic pain. Thus, the proportion of patients free from neuropathic pain was higher in the RA group (63.3%) than in the OA group (39.1%) [p = 0.003]. Both the prevalence and the severity of neuropathic pain were significantly higher in OA than in RA. These findings suggest that neuropathic pain is an important factor in OA, as in RA, and must be considered in management as well as in future research in both these conditions.
摘要：
神经性疼痛可存在于患有骨关节炎(OA)和类风湿性关节炎(RA)的一定比例的患者中。它的存在可能导致在这些条件下需要改变管理方法。这项研究调查了与RA相比，OA中神经性疼痛的患病率。如果OA和RA患者没有其他已知的神经性疾病，则将其纳入横断面。PainDETECT问卷用于评估神经性疼痛。WOMAC和CDAI评分分别用于评估OA和RA的疾病严重程度。比较了69例WOMAC平均得分为53.30±16.39的OA患者和98例CDAI平均为25.48±16.99的RA患者。OA的PainDETECT评分中位数为13（0-30），RA为5（0-37）[p<0.001]。15例OA患者和6例RA患者发生神经性疼痛的可能性高，而15名OA患者和30名RA患者被归类为可能患有神经性疼痛。因此，RA组没有神经性疼痛的患者比例(63.3%)高于OA组(39.1%)[p=0.003].OA的患病率和神经性疼痛的严重程度均明显高于RA。这些结果表明，神经性疼痛是OA的重要因素，在RA中,在这两种情况下，必须在管理和未来的研究中加以考虑。
