Abstract:
People with cystic fibrosis (CF) are at risk for dysglycaemia caused by progressive beta cell dysfunction and destruction due to pancreatic exocrine disease and fibrosis. CF-related diabetes (CFRD) is a unique form of diabetes that has distinctive features from both type 1 and type 2 diabetes. Recent advances in diabetes technology may be of particular benefit in this population given the complex, multi-system organ involvement and challenging health issues that people with CFRD often face. This review summarises how diabetes technologies, such as continuous glucose monitors (CGMs) and insulin delivery devices: (1) have improved our understanding of CFRD, including how hyperglycaemia affects clinical outcomes in people with CF; (2) may be helpful in the screening and diagnosis of CFRD; and (3) offer promise for improving the management of CFRD and easing the burden that this diagnosis can add to an already medically complicated patient population.
摘要:
患有囊性纤维化(CF)的人有因胰腺外分泌疾病和纤维化引起的进行性β细胞功能障碍和破坏引起的血糖异常的风险。CF相关糖尿病(CFRD)是一种独特的糖尿病形式,具有1型和2型糖尿病的独特特征。考虑到复杂的情况,糖尿病技术的最新进展可能对该人群特别有益,CFRD患者经常面临的多系统器官参与和具有挑战性的健康问题。这篇综述总结了糖尿病技术,如连续葡萄糖监测仪(CGMs)和胰岛素输送装置:(1)提高了我们对CFRD的理解,包括高血糖如何影响CF患者的临床结局;(2)可能有助于CFRD的筛查和诊断;(3)为改善CFRD的管理和减轻这种诊断可能给已经复杂的患者群体增加的负担提供了希望.