Abstract：
OBJECTIVE: To evaluate the changes in choroidal thickness 1 year after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) using widefield swept-source optical coherence tomography.
METHODS: We retrospectively reviewed 21 patients with CSC who unilaterally underwent half-dose PDT and completed a 12-month follow-up. Choroidal thickness was evaluated before and after PDT within an 18-mm circular grid centered on the fovea subdivided into nine areas in the treated and untreated fellow eyes.
RESULTS: All 21 treated eyes showed complete resolution of subretinal fluid at 3 months after PDT, without any recurrence at 12 months. The mean choroidal thickness in all nine areas significantly decreased after PDT at 3 months (P < 0.05) and remained unchanged at 12 months (P < 0.05) compared with that at baseline. However, the subtracted choroidal thickness maps between 3 and 12 months detected significant variations among the cases, classified into an enhanced pattern in 10 eyes (47.6%), an attenuated pattern in six eyes (28.6%), and a stable pattern in five eyes (23.8%). The 21 untreated fellow eyes also showed a decrease in mean choroidal thickness in three of the nine subdivided areas at 12 months (P < 0.05), but this decrease was limited posteriorly.
CONCLUSIONS: The reduction in mean choroidal thickness after half-dose PDT for CSC was extensively maintained for 1 year. However, subclinical hemodynamic changes in the entire choroid occurred longitudinally even in the absence of disease recurrence.
METHODS: We retrospectively reviewed 21 patients with CSC who unilaterally underwent half-dose PDT and completed a 12-month follow-up. Choroidal thickness was evaluated before and after PDT within an 18-mm circular grid centered on the fovea subdivided into nine areas in the treated and untreated fellow eyes.
RESULTS: All 21 treated eyes showed complete resolution of subretinal fluid at 3 months after PDT, without any recurrence at 12 months. The mean choroidal thickness in all nine areas significantly decreased after PDT at 3 months (P < 0.05) and remained unchanged at 12 months (P < 0.05) compared with that at baseline. However, the subtracted choroidal thickness maps between 3 and 12 months detected significant variations among the cases, classified into an enhanced pattern in 10 eyes (47.6%), an attenuated pattern in six eyes (28.6%), and a stable pattern in five eyes (23.8%). The 21 untreated fellow eyes also showed a decrease in mean choroidal thickness in three of the nine subdivided areas at 12 months (P < 0.05), but this decrease was limited posteriorly.
CONCLUSIONS: The reduction in mean choroidal thickness after half-dose PDT for CSC was extensively maintained for 1 year. However, subclinical hemodynamic changes in the entire choroid occurred longitudinally even in the absence of disease recurrence.
摘要：
目的：使用宽场扫频源光学相干断层扫描技术评估半剂量光动力疗法（PDT）治疗中心性浆液性脉络膜视网膜病变（CSC）1年后脉络膜厚度的变化。
方法：我们回顾性分析了21例单侧接受半剂量PDT并完成12个月随访的CSC患者。在PDT之前和之后，在中心凹的18毫米圆形网格内评估脉络膜厚度，该网格被细分为治疗和未治疗的眼睛中的9个区域。
结果：所有21只接受治疗的眼睛在PDT后3个月显示视网膜下液完全消退，12个月时无任何复发。所有9个区域的平均脉络膜厚度在PDT后3个月时显著降低(P<0.05),在12个月时保持不变(P<0.05)。然而,在3到12个月之间减去脉络膜厚度图检测到病例之间的显着差异，在10只眼睛中分为增强模式（47.6％），六只眼睛的衰减模式（28.6%），五只眼睛有稳定的模式(23.8%)。21只未经治疗的眼睛在12个月时，9个细分区域中的3个也显示出平均脉络膜厚度降低（P<0.05）。但这种减少是有限的。
结论：CSC半剂量PDT后平均脉络膜厚度的降低广泛维持1年。然而,即使没有疾病复发,整个脉络膜的亚临床血流动力学变化也会纵向发生.
方法：我们回顾性分析了21例单侧接受半剂量PDT并完成12个月随访的CSC患者。在PDT之前和之后，在中心凹的18毫米圆形网格内评估脉络膜厚度，该网格被细分为治疗和未治疗的眼睛中的9个区域。
结果：所有21只接受治疗的眼睛在PDT后3个月显示视网膜下液完全消退，12个月时无任何复发。所有9个区域的平均脉络膜厚度在PDT后3个月时显著降低(P<0.05),在12个月时保持不变(P<0.05)。然而,在3到12个月之间减去脉络膜厚度图检测到病例之间的显着差异，在10只眼睛中分为增强模式（47.6％），六只眼睛的衰减模式（28.6%），五只眼睛有稳定的模式(23.8%)。21只未经治疗的眼睛在12个月时，9个细分区域中的3个也显示出平均脉络膜厚度降低（P<0.05）。但这种减少是有限的。
结论：CSC半剂量PDT后平均脉络膜厚度的降低广泛维持1年。然而,即使没有疾病复发,整个脉络膜的亚临床血流动力学变化也会纵向发生.
