Abstract：
The objective of this study was to understand the utilization pattern of erythropoietin in end-stage renal disease patients, along with the effect of body weight and sex on the patients\' responses. In this retrospective single-center study, 120 patients were included who were on a once weekly (n = 79), twice weekly (n = 37), or thrice weekly (n = 4) regimen. The doses of erythropoiesis-stimulating agents (ESA) were collected, and the erythropoietin resistance index (ERI) was determined. The Kruskal-Wallis test was used to evaluate the dose schedules, and the once-weekly regimen produced a greater response (P = 0.001). The asymptotic significance of Pearson\'s Chi-square-test equating the mean ERI and body mass index (BMI) was 0.034. No statistically significant correlation was estimated between sex and mean ERI (P = 0.201). Our study demonstrated that the once-weekly regimen dominated over the others in terms of efficacy, and individuals with a higher BMI were found to respond better to the ESA therapy.
摘要：
这项研究的目的是了解终末期肾病患者促红细胞生成素的使用模式，以及体重和性别对患者反应的影响。在这项回顾性单中心研究中，120例患者每周一次（n=79），每周两次（n=37），或每周三次（n=4）方案。收集红细胞生成刺激剂（ESA）的剂量，并测定促红细胞生成素抵抗指数(ERI)。Kruskal-Wallis试验用于评估剂量时间表，每周一次的治疗方案产生了更大的反应(P=0.001)。皮尔逊卡方检验的渐近意义等于平均ERI和体重指数（BMI）为0.034。性别与平均ERI之间无统计学意义的相关性（P=0.201）。我们的研究表明，每周一次的方案在疗效方面优于其他方案，并且发现BMI较高的个体对ESA治疗的反应更好.
