Abstract：
Depression is the most common psychiatric disorder in patients on hemodialysis. An imbalance between proinflammatory and anti-inflammatory cytokines is thought to play a role in the pathogenesis of depression in patients on dialysis. We undertook this study to assess the correlations of the proinflammatory cytokine interleukin 6 (IL-6) and the anti-inflammatory cytokine IL-10 with depression in patients on maintenance hemodialysis. This cross-sectional observational study was carried out at our hospital, a tertiary care referral government teaching hospital, over 2 years. Depression was assessed using the Becks Depression Inventory score. A higher cutoff of >16 was taken for a diagnosis of depression. Clinical, demographic, and laboratory parameters were analyzed. Cytokines were assessed using enzyme-linked immunosorbent assays. Eighty patients satisfied the inclusion criteria. The prevalence of depression in our study was 41.5%. Depression was more common in those who were unemployed and/or illiterate. Mild depression was found in patients from the upper-lower and lower-middle classes, but severe depression was seen in lower-economic classes. Serum levels of IL-6 showed a positive correlation with the severity of depression. Depression was common in patients on maintenance hemodialysis. High levels of serum IL-6 were observed in those with depression. Depression in patients on maintenance hemodialysis is associated with a considerable risk of mortality.
摘要：
抑郁症是血液透析患者最常见的精神疾病。促炎和抗炎细胞因子之间的失衡被认为在透析患者的抑郁症的发病机理中起作用。我们进行了这项研究，以评估维持性血液透析患者的促炎细胞因子白细胞介素6（IL-6）和抗炎细胞因子IL-10与抑郁症的相关性。这项横断面观察研究是在我们医院进行的，三级护理转诊政府教学医院，超过2年。使用Becks抑郁量表评分评估抑郁。对于抑郁症的诊断，取更高的临界值>16。临床,人口统计学,并对实验室参数进行了分析。使用酶联免疫吸附测定来评估细胞因子。80例患者符合纳入标准。在我们的研究中，抑郁症的患病率为41.5%。抑郁症在失业和/或文盲的人群中更为常见。在中上阶层和中下阶层的患者中发现了轻度抑郁症，但是严重的抑郁症出现在较低的经济阶层。血清IL-6水平与抑郁症的严重程度呈正相关。抑郁症在维持性血液透析患者中很常见。在抑郁症患者中观察到高水平的血清IL-6。维持性血液透析患者的抑郁症与相当大的死亡风险相关。
