关键词: Crohn’s disease Inflammatory bowel disease biomarker children fecal ulcerative colitis

Mesh : Humans Biomarkers Feces / chemistry Inflammatory Bowel Diseases / diagnosis metabolism Crohn Disease / diagnosis metabolism Colitis, Ulcerative / diagnosis metabolism

来  源:   DOI:10.1080/14737159.2024.2375224

Abstract:
UNASSIGNED: Inflammatory bowel disease (IBD), encompassing Crohn\'s disease (CD) and Ulcerative Colitis (UC), is a relapsing and remitting condition. Noninvasive biomarkers have an increasingly important role in the diagnosis of IBD and in the prediction of future disease course in individuals with IBD. Strategies for the management of IBD increasingly rely upon close monitoring of gastrointestinal inflammation.
UNASSIGNED: This review provides an update on the current understanding of established and novel stool-based biomarkers in the diagnosis and management of IBD. It also highlights key gaps, identifies limitations, and advantages of current markers, and examines aspects that require further study and analysis.
UNASSIGNED: Current noninvasive inflammatory markers play an important role in the diagnosis and management of IBD; however, limitations exist. Future work is required to further characterize and validate current and novel markers of inflammation. In addition, it is essential to better understand the roles and characteristics of noninvasive markers to enable the appropriate selection to accurately determine the condition of the intestinal mucosa.
摘要:
炎症性肠病(IBD),包括克罗恩病(CD)和溃疡性结肠炎(UC),是一种复发和缓解的疾病。非侵入性生物标志物在IBD的诊断和IBD个体未来疾病进程的预测中具有越来越重要的作用。IBD的管理策略越来越依赖于对胃肠道炎症的密切监测。
这篇综述提供了对IBD诊断和管理中已建立和新颖的基于粪便的生物标志物的最新理解。它还突出了关键差距,确定限制,和当前标记的优点,并研究需要进一步研究和分析的方面。
目前的非侵入性炎症标志物在IBD的诊断和治疗中起着重要作用;然而,存在局限性。未来的工作需要进一步表征和验证当前和新的炎症标志物。此外,有必要更好地了解非侵入性标记物的作用和特征,以使适当的选择能够准确地确定肠粘膜的状况。
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