PDF(Pubmed)
Abstract：
Intracellular infection by a pathogen induces significant rewiring of host cell signaling and biological processes. Understanding how an intracellular pathogen such as Toxoplasma gondii modulates host cell metabolism with single-cell resolution has been challenged by the variability of infection within cultures and difficulties in separating host and parasite metabolic processes. A new study from Gallego-Lopez and colleagues (G. M. Gallego-López, E. C. Guzman, D. E. Desa, L. J. Knoll, M. C. Skala, mBio e00727-24, 2024, https://doi.org/10.1128/mbio.00727-24) applies a quantitative imaging approach to evaluate the host cell metabolism during intracellular infection with Toxoplasma. This study provides important insights into host metabolic responses to Toxoplasma infection and offers a valuable tool to dissect the mechanisms underlying parasite infection and pathophysiology.
摘要：
病原体的细胞内感染诱导宿主细胞信号传导和生物过程的显著重新布线。由于培养物中感染的变异性以及分离宿主和寄生虫代谢过程的困难，理解弓形虫等细胞内病原体如何以单细胞分辨率调节宿主细胞代谢受到了挑战。Gallego-Lopez及其同事的一项新研究（G.M.Gallego-López,E.C.Guzman,D.E.Desa,L.J.Knoll,M.C.Skala,mBioe00727-24，2024，https://doi.org/10.1128/mbio.00727-24）应用定量成像方法来评估弓形虫胞内感染期间的宿主细胞代谢。这项研究提供了有关宿主对弓形虫感染的代谢反应的重要见解，并提供了一个有价值的工具来剖析寄生虫感染和病理生理学的潜在机制。
