PDF(Pubmed)
Abstract：
Accumulating evidence indicates that inflammatory and immunologic processes play a significant role in the development and progression of glomerular diseases. Podocytes, the terminally differentiated epithelial cells, are crucial for maintaining the integrity of the glomerular filtration barrier. Once injured, podocytes cannot regenerate, leading to progressive proteinuric glomerular diseases. However, emerging evidence suggests that podocytes not only maintain the glomerular filtration barrier and are important targets of immune responses but also exhibit many features of immune-like cells, where they are involved in the modulation of the activity of innate and adaptive immunity. This dual role of podocytes may lead to the discovery and development of new therapeutic targets for treating glomerular diseases. This review aims to provide an overview of the innate immunity mechanisms involved in podocyte injury and the progression of proteinuric glomerular diseases.
摘要：
越来越多的证据表明，炎症和免疫过程在肾小球疾病的发展和进展中起着重要作用。足细胞,终末分化的上皮细胞，对于维持肾小球滤过屏障的完整性至关重要。一旦受伤,足细胞不能再生,导致进行性蛋白尿肾小球疾病。然而,新出现的证据表明，足细胞不仅维持肾小球滤过屏障，是免疫反应的重要靶标，而且表现出免疫样细胞的许多特征，它们参与先天免疫和适应性免疫活性的调节。足细胞的这种双重作用可能导致发现和开发新的治疗肾小球疾病的治疗靶标。本综述旨在对足细胞损伤和蛋白尿肾小球疾病进展中的先天性免疫机制进行综述。
