PDF(Pubmed)
Abstract：
Breast cancer risk factors include lifestyle, genetic-hormonal influences, and viral infections. Human papillomavirus (HPV), known primarily as the etiological agent of cervical cancer, also appears active in breast carcinogenesis, as evidenced in our study of 56 patients from northeastern Brazil. We assessed the clinical and sociodemographic characteristics, correlating them with various breast cancer tumor types. HPV detection involved amplifying the L1 region, with viral load measured using the E2/E6 ratio and viral activity indicated by E5 oncogene expression. Predominantly, patients over 56 years of age with healthy lifestyles showed a high incidence of invasive ductal carcinoma and triple-negative breast cancer. HPV was detected in 35.7% of cases, mostly HPV16, which is associated with high viral loads (80 copies per cell) and significant E5 expression. These results hint at a possible link between HPV and breast carcinogenesis, necessitating further studies to explore this association and the underlying viral mechanisms.
摘要：
乳腺癌的危险因素包括生活方式，遗传荷尔蒙的影响，和病毒感染。人乳头瘤病毒(HPV),主要被称为宫颈癌的病因，在乳腺癌发生中也表现出活性，我们对巴西东北部56例患者的研究证明了这一点。我们评估了临床和社会人口统计学特征，将它们与各种乳腺癌肿瘤类型相关联。HPV检测涉及放大L1区，使用E2/E6比率测量的病毒载量和由E5癌基因表达指示的病毒活性。主要是,56岁以上且生活方式健康的患者,浸润性导管癌和三阴性乳腺癌的发病率较高.在35.7%的病例中检测到HPV，主要是HPV16，这与高病毒载量（每个细胞80个拷贝）和显着的E5表达有关。这些结果提示HPV和乳腺癌之间可能存在联系。需要进一步的研究来探索这种关联和潜在的病毒机制。
