PDF(Pubmed)
Abstract：
There has been a significant increase in the consumption of cannabis for both recreational and medicinal purposes in recent years, and its use can have long-term consequences on cognitive functions, including memory. Here, we review the immediate and long-term effects of cannabis and its derivatives on glutamatergic neurotransmission, with a focus on both the presynaptic and postsynaptic alterations. Several factors can influence cannabinoid-mediated changes in glutamatergic neurotransmission, including dosage, sex, age, and frequency of use. Acute exposure to cannabis typically inhibits glutamate release, whereas chronic use tends to increase glutamate release. Conversely, the postsynaptic alterations are more complicated than the presynaptic effects, as cannabis can affect the glutamate receptor expression and the downstream signaling of glutamate. All these effects ultimately influence cognitive functions, particularly memory. This review will cover the current research on glutamate-cannabis interactions, as well as the future directions of research needed to understand cannabis-related health effects and neurological and psychological aspects of cannabis use.
摘要：
近年来用于娱乐和医疗目的的大麻消费量大幅增加,它的使用会对认知功能产生长期影响，包括记忆。这里,我们回顾了大麻及其衍生物对谷氨酸能神经传递的直接和长期影响，重点是突触前和突触后的改变。几个因素可以影响大麻素介导的谷氨酸能神经传递的变化，包括剂量，性别,年龄,和使用频率。急性接触大麻通常会抑制谷氨酸释放，而长期使用往往会增加谷氨酸释放。相反，突触后改变比突触前效应更复杂，因为大麻可以影响谷氨酸受体的表达和谷氨酸的下游信号传导。所有这些影响最终影响认知功能，尤其是记忆。这篇综述将涵盖目前对谷氨酸-大麻相互作用的研究，以及了解与大麻相关的健康影响以及大麻使用的神经和心理方面所需的未来研究方向。
