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Abstract：
Human papillomavirus (HPV)-positive Head and Neck Squamous Cell Carcinomas (HNSCC) comprise a particular cancer entity traditionally associated with better clinical outcomes. Around 25% of HNSCC are HPV positive, HPV16 being the most prevalent type. Nevertheless, close to 30% of the HPV-positive patients have an unfavorable prognosis, revealing that this type of tumor exhibits great heterogeneity leading to different clinical behaviors. Efforts have been made to identify RNA molecules with prognostic value associated with the clinical outcome of patients with HPV-positive HNSCC, with the aim of identifying patients at high risk of metastasis, disease recurrence, and poor survival, who would require closer clinical follow-up and timely intervention. Moreover, the molecular identification of those HPV-positive HNSCC patients with good prognosis will allow the implementation of de-escalating therapeutic strategies, aiming to reduce side effects, resulting in a better quality of life. This review compiles a series of recent studies addressing different methodological and conceptual approaches aimed at searching for potential gene expression-based biomarkers associated with the prognosis of patients with HPV-positive HNSCC.
摘要：
人乳头瘤病毒(HPV)阳性头颈部鳞状细胞癌(HNSCC)包括传统上与更好的临床结果相关的特定癌症实体。大约25%的HNSCC是HPV阳性。HPV16是最普遍的类型。然而，接近30%的HPV阳性患者预后不良,揭示了这种类型的肿瘤表现出巨大的异质性，导致不同的临床行为。已经努力鉴定与HPV阳性HNSCC患者的临床结果相关的具有预后价值的RNA分子。为了识别转移风险高的患者，疾病复发,可怜的生存，谁需要更密切的临床随访和及时干预。此外，那些具有良好预后的HPV阳性HNSCC患者的分子鉴定将允许实施降级治疗策略，旨在减少副作用，带来更好的生活质量。这篇综述汇编了一系列针对不同方法和概念方法的最新研究，旨在寻找与HPV阳性HNSCC患者预后相关的潜在基于基因表达的生物标志物。
