PDF(Pubmed)
Abstract：
This review describes and summarizes, for the first time, the molecular mechanisms of the cytotoxic effect of selenium nanoparticles of various origins on hepatocellular carcinoma cells. The text provides information from recent years indicating the regulation of various signaling pathways and endoplasmic reticulum stress by selenium nanoparticles; the pathways of cell death of liver cancer cells as a result of exposure to selenium nanoparticles are considered. Particular attention is paid to the participation of selenoproteins and selenium-containing thioredoxin reductases and glutathione peroxidases in these processes. Previously, there were no reviews that fully reflected the cytotoxic effects of selenium nanoparticles specifically in hepatocellular carcinoma, despite the fact that many reviews and experimental articles have been devoted to the causes of this disease and the molecular mechanisms of regulation of cytotoxic effects by other agents. The relevance of this review is primarily explained by the fact that despite the development of various drugs and approaches for the treatment and prevention of hepatocellular carcinoma, this disease is still the fourth leading cause of death in the world. For this reason, a complete understanding of the latest trends in the treatment of oncology of various etiologies, especially hepatocellular carcinoma, is extremely important.
摘要：
这篇综述描述和总结了，第一次,不同来源的纳米硒对肝癌细胞的细胞毒性作用的分子机制。本文提供了近年来的信息，表明硒纳米颗粒对各种信号传导途径和内质网应激的调节；考虑了由于暴露于硒纳米颗粒而导致的肝癌细胞死亡的途径。特别注意硒蛋白和含硒的硫氧还蛋白还原酶和谷胱甘肽过氧化物酶在这些过程中的参与。以前,没有评论充分反映硒纳米颗粒在肝细胞癌中的细胞毒性作用，尽管许多评论和实验文章都致力于这种疾病的原因以及其他药物调节细胞毒性作用的分子机制。这篇综述的相关性主要解释为尽管开发了各种药物和方法来治疗和预防肝细胞癌，这种疾病仍然是世界上第四大死亡原因。出于这个原因,全面了解各种病因肿瘤学治疗的最新趋势，尤其是肝细胞癌，是极其重要的。
