PDF(Pubmed)
Abstract：
The RFamide peptide family is a group of proteins that share a common C-terminal arginine-phenylalanine-amide motif. To date, the family comprises five groups in mammals: neuropeptide FF, LPXRFamides/RFamide-related peptides, prolactin releasing peptide, QRFP, and kisspeptins. Different RFamide peptides have their own cognate receptors and are produced by different cell populations, although they all can also bind to neuropeptide FF receptors with different affinities. RFamide peptides function in the brain as neuropeptides regulating key aspects of homeostasis such as energy balance, reproduction, and cardiovascular function. Furthermore, they are involved in the organization of the stress response including modulation of pain. Considering the interaction between stress and various parameters of homeostasis, the role of RFamide peptides may be critical in the development of stress-related neuropathologies. This review will therefore focus on the role of RFamide peptides as possible key hubs in stress and stress-related psychopathologies. The neurotransmitter coexpression profile of RFamide-producing cells is also discussed, highlighting its potential functional significance. The development of novel pharmaceutical agents for the treatment of stress-related disorders is an ongoing need. Thus, the importance of RFamide research is underlined by the emergence of peptidergic and G-protein coupled receptor-based therapeutic targets in the pharmaceutical industry.
摘要：
RFamide肽家族是一组共有一个共同的C-末端精氨酸-苯丙氨酸-酰胺基序的蛋白质。迄今为止,该家族在哺乳动物中包括五组：神经肽FF，LPXRFamides/RFamide相关肽，催乳素释放肽，QRFP,和kisspeptins.不同的RFamide肽有自己的同源受体，由不同的细胞群体产生，尽管它们都可以以不同的亲和力与神经肽FF受体结合。RFamide肽在大脑中作为神经肽调节稳态的关键方面，如能量平衡，繁殖，和心血管功能。此外，他们参与组织应激反应，包括调节疼痛。考虑到压力和体内平衡的各种参数之间的相互作用，RFamide肽的作用可能在应激相关神经病变的发展中至关重要。因此，本文将重点关注RFamide肽作为压力和压力相关精神病理学中可能的关键枢纽的作用。还讨论了RFamide产生细胞的神经递质共表达谱，强调其潜在的功能意义。持续需要开发用于治疗应激相关病症的新型药物。因此，制药行业中基于肽能和G蛋白偶联受体的治疗靶标的出现强调了RFamide研究的重要性。
