Abstract：
UNASSIGNED: Endometrial carcinoma (EC) is a typical gynecological malignant tumor that occurs more frequently every year. Obesity is a significant contributor to the development of EC and its prognosis. Lipid metabolism and malignant tumors have a long history of association. Elevated cholesterol levels are made possible by adenosine triphosphate-binding cassette protein A1 (ABCA1) deficiency, which eventually promotes cancer cell survival. The aim of this study was to examine at the ABCA1 gene expression levels in EC patients. The relationship between ABCA1 and the occurrence, progression, and prognosis of EC is discussed in this article as a potential mechanism.
UNASSIGNED: The samples of 45 endometrial adenocarcinoma patients were retrospectively included in this study and they were further divided into Grade 1 (15), Grade 2 (15), Grade 3 (15) tumors, control group. Twenty-nine endometrial tissues without a confirmed diagnosis of endometrial cancer made up the control group. ABCA1 gene expression was examined using real-time polymerase chain reaction.
UNASSIGNED: According to the results, the gene expressions of the patient group were higher than the control group When each Grade was compared with the control group, statistically significant results were obtained. After analyzing the data, it was found that the patient group was generally higher than the control group (p < 0.05) and there were differences in the grades of the patient group (p < 0.05). When the ABCA1 expressions of the grade groups and control groups were compared separately, a difference was found between Grade 1, Grade 2 and Grade 3 and the control group (p= 0.0001).
UNASSIGNED: According to the findings of our study, a key component in the growth of EC tumors is the increase in cholesterol production caused by a reduction in ABCA1.
UNASSIGNED: The samples of 45 endometrial adenocarcinoma patients were retrospectively included in this study and they were further divided into Grade 1 (15), Grade 2 (15), Grade 3 (15) tumors, control group. Twenty-nine endometrial tissues without a confirmed diagnosis of endometrial cancer made up the control group. ABCA1 gene expression was examined using real-time polymerase chain reaction.
UNASSIGNED: According to the results, the gene expressions of the patient group were higher than the control group When each Grade was compared with the control group, statistically significant results were obtained. After analyzing the data, it was found that the patient group was generally higher than the control group (p < 0.05) and there were differences in the grades of the patient group (p < 0.05). When the ABCA1 expressions of the grade groups and control groups were compared separately, a difference was found between Grade 1, Grade 2 and Grade 3 and the control group (p= 0.0001).
UNASSIGNED: According to the findings of our study, a key component in the growth of EC tumors is the increase in cholesterol production caused by a reduction in ABCA1.
摘要：
■子宫内膜癌（EC）是一种典型的妇科恶性肿瘤，每年发生频率更高。肥胖是EC发展及其预后的重要因素。脂质代谢与恶性肿瘤有着悠长的关联史。三磷酸腺苷结合盒蛋白A1（ABCA1）缺乏使胆固醇水平升高成为可能，最终促进癌细胞存活。这项研究的目的是检查EC患者的ABCA1基因表达水平。ABCA1与发生的关系，programming,本文讨论了EC的预后，并将其作为一种潜在的机制。
■本研究回顾性纳入45例子宫内膜腺癌患者的样本，并将其进一步分为1级（15），二级(15)3级（15）肿瘤，对照组。29个未确诊子宫内膜癌的子宫内膜组织构成对照组。使用实时聚合酶链反应检查ABCA1基因表达。
■根据结果，患者组的基因表达高于对照组。获得了具有统计学意义的结果。在分析了数据之后,结果发现，患者组普遍高于对照组（p<0.05），并且患者组的等级存在差异（p<0.05）。当分别比较分级组和对照组的ABCA1表达时，发现1级，2级和3级与对照组之间存在差异（p=0.0001）。
■根据我们的研究结果，EC肿瘤生长的一个关键因素是ABCA1减少引起的胆固醇产生增加.
■本研究回顾性纳入45例子宫内膜腺癌患者的样本，并将其进一步分为1级（15），二级(15)3级（15）肿瘤，对照组。29个未确诊子宫内膜癌的子宫内膜组织构成对照组。使用实时聚合酶链反应检查ABCA1基因表达。
■根据结果，患者组的基因表达高于对照组。获得了具有统计学意义的结果。在分析了数据之后,结果发现，患者组普遍高于对照组（p<0.05），并且患者组的等级存在差异（p<0.05）。当分别比较分级组和对照组的ABCA1表达时，发现1级，2级和3级与对照组之间存在差异（p=0.0001）。
■根据我们的研究结果，EC肿瘤生长的一个关键因素是ABCA1减少引起的胆固醇产生增加.
