PDF(Pubmed)
Abstract：
UNASSIGNED: To assess the association between kidney function and odds of having low skeletal muscle mass (LSMM) in Chinese adults on the basis of a community study.
UNASSIGNED: In this cross-sectional study, we included 3726 Chinese older persons who participated in an ongoing prospective study, the China Health and Retirement Longitudinal Study(CHARLS). Fasting blood samples were collected in 2012 and analyzed for serum creatinine. Estimated glomerular filtration rate(eGFR) was computed using serum creatinine, gender, and age, according to the 2021 race-free Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). We classified the target population into three categories according to eGFR (normal eGFR;90mL/min/1.73m2, mildly-impaired eGFR;60 to < 90 mL/min/1.73 m2, moderate to severve impaired eGFR;<60 mL/min/1.73 m2). BMI-adjusted muscle mass was used to measure skeletal muscle mass.The association between eGFR(per interquartile range(IQR) increment) and the risk of low skeletal muscle mass was assessed using logistic regression model.
UNASSIGNED: Worsening renal function was associated with being high risk for LSMM after adjusting for potential confounders:the odds ratios (ORs) 95% confidence intervals (CIs) were 0.76 (95% CI = 0.63 - 0.88) for male, and [0.71, (0.61-0.82)]in female, p < 0.001. Specifically, male participants with mildly renal impairment were more prone to develop LSMM (multiadjusted OR, 1.43, 95% CI(0.92 to 2.09), p = 0.1) than femal(multiadjusted OR, 1.32, 95% CI(0.85 to 2.00), p = 0.2), the gender difference was not significant in severe renal dysfunction.However, there was a non-linear relationship between eGFR(per IQR increment) and risk of LSMM(eGFR/IQR =5.42, knot = 4 OR =1, p for non-linear <0.001).
UNASSIGNED: Lower levels of eGFR had a high likelihood of being high risk for LSMM. Older male patients with mildly renal insufficiency are more likely to experience a decrease in skeletal muscle mass compared to female.
UNASSIGNED: In this cross-sectional study, we included 3726 Chinese older persons who participated in an ongoing prospective study, the China Health and Retirement Longitudinal Study(CHARLS). Fasting blood samples were collected in 2012 and analyzed for serum creatinine. Estimated glomerular filtration rate(eGFR) was computed using serum creatinine, gender, and age, according to the 2021 race-free Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). We classified the target population into three categories according to eGFR (normal eGFR;90mL/min/1.73m2, mildly-impaired eGFR;60 to < 90 mL/min/1.73 m2, moderate to severve impaired eGFR;<60 mL/min/1.73 m2). BMI-adjusted muscle mass was used to measure skeletal muscle mass.The association between eGFR(per interquartile range(IQR) increment) and the risk of low skeletal muscle mass was assessed using logistic regression model.
UNASSIGNED: Worsening renal function was associated with being high risk for LSMM after adjusting for potential confounders:the odds ratios (ORs) 95% confidence intervals (CIs) were 0.76 (95% CI = 0.63 - 0.88) for male, and [0.71, (0.61-0.82)]in female, p < 0.001. Specifically, male participants with mildly renal impairment were more prone to develop LSMM (multiadjusted OR, 1.43, 95% CI(0.92 to 2.09), p = 0.1) than femal(multiadjusted OR, 1.32, 95% CI(0.85 to 2.00), p = 0.2), the gender difference was not significant in severe renal dysfunction.However, there was a non-linear relationship between eGFR(per IQR increment) and risk of LSMM(eGFR/IQR =5.42, knot = 4 OR =1, p for non-linear <0.001).
UNASSIGNED: Lower levels of eGFR had a high likelihood of being high risk for LSMM. Older male patients with mildly renal insufficiency are more likely to experience a decrease in skeletal muscle mass compared to female.
摘要：
■根据一项社区研究，评估中国成年人肾功能与骨骼肌质量低（LSMM）的几率之间的关联。
■在这项横断面研究中，我们纳入了3726名中国老年人，他们参与了一项正在进行的前瞻性研究，中国健康与退休纵向研究(CHARLS)。2012年采集空腹血样并分析血清肌酐。估计的肾小球滤过率（eGFR）使用血清肌酐计算，性别,和年龄,根据2021年无种族慢性肾脏病流行病学合作方程（CKD-EPI）。我们根据eGFR将目标人群分为三类（正常eGFR;90mL/min/1.73m2，轻度受损eGFR;60至<90mL/min/1.73m2，中度至严重受损eGFR;<60mL/min/1.73m2）。BMI调整后的肌肉质量用于测量骨骼肌质量。使用逻辑回归模型评估eGFR（每四分位距（IQR）增量）与低骨骼肌质量风险之间的关联。
■在调整了潜在的混杂因素后，肾功能恶化与LSMM的高风险相关：男性的比值比（ORs）95％置信区间（CI）为0.76（95％CI=0.63-0.88），和[0.71，（0.61-0.82）]女性，p<0.001。具体来说,轻度肾功能损害的男性参与者更容易发展为LSMM(多重校正OR，1.43，95%CI（0.92至2.09），p=0.1)比女性(多重调整OR，1.32，95%CI（0.85至2.00），p=0.2),严重肾功能不全患者的性别差异不显著。然而,eGFR(每IQR增量)与LSMM风险之间存在非线性关系(eGFR/IQR=5.42,node=4OR=1,p表示非线性<0.001).
■较低水平的eGFR很可能是LSMM的高风险。与女性相比，患有轻度肾功能不全的老年男性患者更有可能经历骨骼肌质量的减少。
■在这项横断面研究中，我们纳入了3726名中国老年人，他们参与了一项正在进行的前瞻性研究，中国健康与退休纵向研究(CHARLS)。2012年采集空腹血样并分析血清肌酐。估计的肾小球滤过率（eGFR）使用血清肌酐计算，性别,和年龄,根据2021年无种族慢性肾脏病流行病学合作方程（CKD-EPI）。我们根据eGFR将目标人群分为三类（正常eGFR;90mL/min/1.73m2，轻度受损eGFR;60至<90mL/min/1.73m2，中度至严重受损eGFR;<60mL/min/1.73m2）。BMI调整后的肌肉质量用于测量骨骼肌质量。使用逻辑回归模型评估eGFR（每四分位距（IQR）增量）与低骨骼肌质量风险之间的关联。
■在调整了潜在的混杂因素后，肾功能恶化与LSMM的高风险相关：男性的比值比（ORs）95％置信区间（CI）为0.76（95％CI=0.63-0.88），和[0.71，（0.61-0.82）]女性，p<0.001。具体来说,轻度肾功能损害的男性参与者更容易发展为LSMM(多重校正OR，1.43，95%CI（0.92至2.09），p=0.1)比女性(多重调整OR，1.32，95%CI（0.85至2.00），p=0.2),严重肾功能不全患者的性别差异不显著。然而,eGFR(每IQR增量)与LSMM风险之间存在非线性关系(eGFR/IQR=5.42,node=4OR=1,p表示非线性<0.001).
■较低水平的eGFR很可能是LSMM的高风险。与女性相比，患有轻度肾功能不全的老年男性患者更有可能经历骨骼肌质量的减少。
