PDF(Pubmed)
Abstract：
Acyl‑coenzyme A thioesterases (ACOTs) are crucial in mediating lipid metabolic functions, including energy expenditure, hepatic gluconeogenesis and neuronal function. The two distinct types are type I and II ACOTs, the latter of which are \'hotdog\' fold superfamily members. Type II ACOTs include carboxyl‑terminal modulator protein 1 (CTMP1), also termed thioesterase superfamily member 4 (THEM4), and CTMP2, also termed THEM5. Due to their similar structural features and distinct sequence homology, CTMP1 and CTMP2 stand out from other type II ACOTs. CTMP1 was initially known as a protein kinase B (PKB) inhibitor that attenuates PKB phosphorylation. PKB is the central regulator of various cellular functions, including survival, proliferation, growth and metabolism. Therefore, by inhibiting PKB, CTMP1 can affect various cellular processes. Various other functions of CTMP1 have been revealed, including functions in cancer, brain injury, mitochondrial function and lipid metabolism. CTMP2 is a paralog of CTMP1 and was first identified as a cardiolipin remodeling factor involved in the development of fatty liver. As the functions of CTMP1 and CTMP2 were discovered separately, a review to summarize and connect these findings is essential. The current review delineates the intricate complexity of CTMP regulation across different metabolic pathways and encapsulates the principal discoveries concerning CTMP until the present day.
摘要：
酰基辅酶A硫酯酶（ACOT）在介导脂质代谢功能方面至关重要，包括能量消耗，肝糖异生和神经元功能。两种不同的类型是I型和II型ACOT，后者是“热狗”的超级家庭成员。II型ACOT包括羧基末端调节蛋白1（CTMP1），也称为硫酯酶超家族成员4（THEM4），和CTMP2，也称为THEM5。由于它们相似的结构特征和不同的序列同源性，CTMP1和CTMP2从其他II型ACOT中脱颖而出。CTMP1最初被称为蛋白激酶B(PKB)抑制剂,其减弱PKB磷酸化。PKB是各种细胞功能的中央调节因子,包括生存,扩散,生长和新陈代谢。因此,通过抑制PKB，CTMP1可以影响各种细胞过程。CTMP1的各种其他功能已经被揭示，包括癌症的功能，脑损伤,线粒体功能和脂质代谢。CTMP2是CTMP1的旁系同源物，首次被确定为参与脂肪肝发展的心磷脂重塑因子。由于CTMP1和CTMP2的功能是分开发现的，总结和联系这些发现至关重要。当前的综述描述了CTMP调节在不同代谢途径中的复杂复杂性，并囊括了迄今为止关于CTMP的主要发现。
