PDF(Pubmed)
Abstract：
In years of research on classical pathways, the composition, information transmission mechanism, crosstalk with other pathways, and physiological and pathological effects of hedgehog (HH) pathway have been gradually clarified. HH also plays a critical role in tumor formation and development. According to the update of interpretation of tumor phenotypes, the latest relevant studies have been sorted out, to explore the specific mechanism of HH pathway in regulating different tumor phenotypes through gene mutation and signal regulation. The drugs and natural ingredients involved in regulating HH pathway were also reviewed; five approved drugs and drugs under research exert efficacy by blocking HH pathway, and at least 22 natural components have potential to treat tumors by HH pathway. Nevertheless, there is a deficiency of existing studies. The present review confirmed the great potential of HH pathway in future cancer treatment with factual basis.
摘要：
在多年对经典途径的研究中，组成,信息传输机制，与其他通路的串扰，Hedgehog（HH）通路的生理和病理效应已逐渐阐明。HH在肿瘤形成和发展中也起关键作用。根据肿瘤表型的最新解释，最新的相关研究已经整理，探讨HH通路通过基因突变和信号调控调控不同肿瘤表型的具体机制。综述了参与调节HH途径的药物和天然成分;5种已批准的药物和正在研究的药物通过阻断HH途径发挥功效,和至少22种天然成分具有通过HH途径治疗肿瘤的潜力。然而，现有研究存在不足。本综述证实了HH通路在未来癌症治疗中的巨大潜力。
