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Abstract：
Spinal diseases, including intervertebral disc degeneration (IDD), ankylosing spondylitis, spinal cord injury and other non‑infectious spinal diseases, severely affect the quality of life of patients. Current treatments for IDD and other spinal diseases can only relieve symptoms and do not completely cure the disease. Therefore, there is an urgent need to explore the causes of these diseases and develop new treatment approaches. Long non‑coding RNA (lncRNA), a form of non‑coding RNA, is abundant in diverse sources, has numerous functions, and plays an important role in the occurrence and development of spinal diseases such as IDD. However, the mechanism of action of lncRNAs has not been fully elucidated, and significant challenges remain in the use of lncRNAs as new therapeutic targets. The present article reviews the sources, classification and functions of lncRNAs, and introduces the role of lncRNAs in spinal diseases, such as IDD, and their therapeutic potential.
摘要：
脊柱疾病,包括椎间盘退变（IDD），强直性脊柱炎,脊髓损伤和其他非感染性脊柱疾病，严重影响患者的生活质量。目前对IDD和其他脊柱疾病的治疗只能缓解症状，不能完全治愈疾病。因此,迫切需要探索这些疾病的原因并开发新的治疗方法。长链非编码RNA(lncRNA)，一种非编码RNA，来源丰富多样，有许多功能，在IDD等脊柱疾病的发生发展中起着重要作用。然而,lncRNAs的作用机制尚未完全阐明，在使用lncRNAs作为新的治疗靶标方面仍然存在重大挑战。本文回顾了来源，lncRNAs的分类和功能，并介绍了lncRNAs在脊柱疾病中的作用，例如IDD，和他们的治疗潜力。
