PDF(Pubmed)
Abstract：
Cancer is characterized by unlimited proliferation and metastasis, and traditional therapeutic strategies usually result in the acquisition of drug resistance, thus highlighting the need for more personalized treatment. mRNA vaccines transfer the gene sequences of exogenous target antigens into human cells through transcription and translation to stimulate the body to produce specific immune responses against the encoded proteins, so as to enable the body to obtain immune protection against said antigens; this approach may be adopted for personalized cancer therapy. Since the recent coronavirus pandemic, the development of mRNA vaccines has seen substantial progress and widespread adoption. In the present review, the development of mRNA vaccines, their mechanisms of action, factors influencing their function and the current clinical applications of the vaccine are discussed. A focus is placed on the application of mRNA vaccines in cancer, with the aim of highlighting unique advances and the remaining challenges of this novel and promising therapeutic approach.
摘要：
癌症的特点是无限的增殖和转移，传统的治疗策略通常会导致耐药性的产生，从而凸显了对更个性化治疗的需求。mRNA疫苗通过转录和翻译将外源靶抗原的基因序列转移到人细胞中，以刺激机体产生针对编码蛋白的特异性免疫反应，从而使机体获得针对所述抗原的免疫保护;这种方法可用于个性化癌症治疗。自从最近的冠状病毒大流行以来，mRNA疫苗的开发已经取得了实质性进展和广泛采用。在本次审查中，mRNA疫苗的发展，他们的行动机制，对影响其功能的因素和目前疫苗的临床应用进行了讨论。重点放在mRNA疫苗在癌症中的应用上，旨在强调这种新颖且有前途的治疗方法的独特进展和剩余挑战。
