Abstract：
The ovaries are key steroid hormone production sites in post-pubertal females. However, current research on steroidogenic enzymes, endogenous hormone concentrations and their effects on healthy ovarian function and malignant development is limited. Here, we discuss the importance of steroid enzymes in normal and malignant ovaries, alongside hormone concentrations, receptor expression and action. Key enzymes include STS, 3β-HSD2, HSD17B1, ARK1C3, and aromatase, which influence ovarian steroidal action. Both androgen and oestrogen action, via their facilitating enzyme, drives ovarian follicle activation, development and maturation in healthy ovarian tissue. In ovarian cancer, some data suggest STS and oestrogen receptor α may be linked to aggressive forms, while various oestrogen-responsive factors may be involved in ovarian cancer metastasis. In contrast, androgen receptor expression and action vary across ovarian cancer subtypes. For future studies investigating steroidogenesis and steroidal activity in ovarian cancer, it is necessary to differentiate between disease subtypes for a comprehensive understanding.
摘要：
卵巢是青春期后女性的关键类固醇激素产生部位。然而,类固醇生成酶的研究现状，内源性激素浓度及其对健康卵巢功能和恶性发育的影响是有限的。这里,我们讨论了类固醇酶在正常和恶性卵巢中的重要性，除了激素浓度，受体的表达和作用。关键酶包括STS,3β-HSD2、HSD17B1、ARK1C3和芳香化酶，影响卵巢类固醇作用。雄激素和雌激素都有作用，通过它们的促进酶，驱动卵泡激活，在健康的卵巢组织中发育和成熟。在卵巢癌中，一些数据表明STS和雌激素受体α可能与侵袭性形式有关，而各种雌激素反应因子可能与卵巢癌转移有关。相比之下,雄激素受体的表达和作用因卵巢癌亚型而异。对于研究卵巢癌中类固醇生成和类固醇活性的未来研究，为了全面了解疾病亚型，有必要区分疾病亚型。
