PDF(Pubmed)
Abstract：
BackgroundAs Ireland prepared for an autumn 2023 COVID-19 vaccination booster campaign, there was concern that vaccine fatigue would affect uptake, which has been abating.AimThis study aimed to quantify the direct impact of the COVID-19 vaccination programme in Ireland on averted COVID-19-related outcomes including symptomatic presentations to primary care/community testing centres, emergency department (ED) presentations, hospitalisations, intensive care unit (ICU) admissions and deaths, in individuals aged ≥ 50 years, during Omicron dominance.MethodsWe conducted a retrospective observational COVID-19 vaccine impact study in December 2021-March 2023 in Ireland. We used national data on notified outcomes and vaccine coverage, as well as vaccine effectiveness (VE) estimates, sourced from the World Health Organization\'s live systematic review of VE, to estimate the count and prevented fraction of outcomes in ≥ 50-year-olds averted by the COVID-19 vaccination programme in this age group.ResultsThe COVID-19 vaccination programme averted 48,551 symptomatic COVID-19 presentations to primary care/community testing centres (36% of cases expected in the absence of vaccination), 9,517 ED presentations (53% of expected), 102,160 hospitalisations (81% of expected), 3,303 ICU admissions (89% of expected) and 15,985 deaths (87% of expected).ConclusionsWhen Omicron predominated, the COVID-19 vaccination programme averted symptomatic and severe COVID-19 cases, including deaths due to COVID-19. In line with other international vaccine impact studies, these findings emphasise the benefits of COVID-19 vaccination for population health and the healthcare system and are relevant for informing COVID-19 booster vaccination programmes, pandemic preparedness and communicating the reason for and importance of COVID-19 vaccination in Ireland and internationally.
摘要：
背景随着爱尔兰为2023年秋季COVID-19疫苗接种加强运动做准备，有人担心疫苗疲劳会影响摄取，这一直在减弱。本研究旨在量化爱尔兰COVID-19疫苗接种计划对避免的COVID-19相关结局的直接影响，包括向初级保健/社区检测中心提出的症状，急诊科（ED）介绍，住院治疗,重症监护病房（ICU）入院和死亡，在年龄≥50岁的个体中，在Omicron统治期间。方法我们于2021年12月至2023年3月在爱尔兰进行了一项回顾性观察性COVID-19疫苗影响研究。我们使用了通知结果和疫苗覆盖率的国家数据，以及疫苗有效性(VE)估计，来自世界卫生组织对VE的实时系统评价，评估该年龄组COVID-19疫苗接种计划避免的≥50岁人群结局的计数和预防比例。结果COVID-19疫苗接种计划避免了向初级保健/社区检测中心提供的48,551例有症状的COVID-19（预计没有疫苗接种的病例中有36％），9,517个ED演讲（占预期的53％），102,160例住院（预期的81％），3,303例ICU入院（占预期的89％）和15,985例死亡（占预期的87％）。结论当Omicron占主导地位时，COVID-19疫苗接种计划避免了有症状和严重的COVID-19病例，包括COVID-19导致的死亡。与其他国际疫苗影响研究一致，这些发现强调了COVID-19疫苗接种对人口健康和医疗保健系统的益处，并与告知COVID-19加强疫苗接种计划有关，大流行的准备，并在爱尔兰和国际上传达COVID-19疫苗接种的原因和重要性。
