PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this retrospective single-center study was to determine the frequency of sarcopenia and its association with mortality and other morbidities in children with chronic liver disease who had undergone liver transplantation.
UNASSIGNED: Sarcopenia, a muscle-wasting syndrome, is common in patients with advanced liver disease and is associated with increased morbidity and mortality. While sarcopenia in adults has been extensively studied, there is little information in this regard about children and adolescents with chronic liver diseases.
UNASSIGNED: The study included 108 children and adolescents who had undergone liver transplantation. Sarcopenia was measured using skeletal muscle index at the third lumbar vertebral level and assessed using abdominal computed tomography imaging.
UNASSIGNED: The frequency of sarcopenia in the studied population was found to be 45.7%. Patients with sarcopenia were more likely to be male (P<0.0001), older (P<0.0001), and had lower height-for-age z-scores (P=0.012). Genetic/metabolic diseases were the most common underlying cause of sarcopenia in children. Except for a higher rate of transplant rejection in the sarcopenia group (P=0.035), there was no significant difference in mortality rates (P=0.688) or post-LT complications between the two groups. One year after LT, computed tomography-derived body composition parameters revealed no significant differences between children who survived and those who did not.
UNASSIGNED: Our findings indicated a high frequency of sarcopenia in children with chronic liver disease, implying that more research is needed to better understand its impact on clinical outcomes in this population.
UNASSIGNED: Sarcopenia, a muscle-wasting syndrome, is common in patients with advanced liver disease and is associated with increased morbidity and mortality. While sarcopenia in adults has been extensively studied, there is little information in this regard about children and adolescents with chronic liver diseases.
UNASSIGNED: The study included 108 children and adolescents who had undergone liver transplantation. Sarcopenia was measured using skeletal muscle index at the third lumbar vertebral level and assessed using abdominal computed tomography imaging.
UNASSIGNED: The frequency of sarcopenia in the studied population was found to be 45.7%. Patients with sarcopenia were more likely to be male (P<0.0001), older (P<0.0001), and had lower height-for-age z-scores (P=0.012). Genetic/metabolic diseases were the most common underlying cause of sarcopenia in children. Except for a higher rate of transplant rejection in the sarcopenia group (P=0.035), there was no significant difference in mortality rates (P=0.688) or post-LT complications between the two groups. One year after LT, computed tomography-derived body composition parameters revealed no significant differences between children who survived and those who did not.
UNASSIGNED: Our findings indicated a high frequency of sarcopenia in children with chronic liver disease, implying that more research is needed to better understand its impact on clinical outcomes in this population.
摘要：
■这项回顾性单中心研究的目的是确定接受肝移植的慢性肝病患儿中肌肉减少症的发生率及其与死亡率和其他疾病的关系。
■肌肉减少症，肌肉萎缩综合征,在晚期肝病患者中很常见，并且与发病率和死亡率增加有关。虽然对成人的肌少症进行了广泛的研究，在这方面，关于儿童和青少年慢性肝病的信息很少。
■该研究包括108名接受肝移植的儿童和青少年。使用第三腰椎水平的骨骼肌指数测量肌肉减少症，并使用腹部计算机断层扫描成像进行评估。
■研究人群中肌肉减少症的发生率为45.7%。肌肉减少症患者更可能是男性（P<0.0001）。年龄较大（P<0.0001），身高年龄z评分较低（P=0.012）。遗传/代谢疾病是儿童少肌症最常见的潜在病因。除肌肉减少组较高的移植排斥率(P=0.035)外,两组间死亡率(P=0.688)或LT术后并发症无显著差异.LT一年后，计算机断层扫描得出的身体成分参数显示,存活儿童和未存活儿童之间没有显著差异.
■我们的研究结果表明慢性肝病患儿出现少肌症的频率很高，这意味着需要更多的研究来更好地了解其对该人群临床结局的影响.
■肌肉减少症，肌肉萎缩综合征,在晚期肝病患者中很常见，并且与发病率和死亡率增加有关。虽然对成人的肌少症进行了广泛的研究，在这方面，关于儿童和青少年慢性肝病的信息很少。
■该研究包括108名接受肝移植的儿童和青少年。使用第三腰椎水平的骨骼肌指数测量肌肉减少症，并使用腹部计算机断层扫描成像进行评估。
■研究人群中肌肉减少症的发生率为45.7%。肌肉减少症患者更可能是男性（P<0.0001）。年龄较大（P<0.0001），身高年龄z评分较低（P=0.012）。遗传/代谢疾病是儿童少肌症最常见的潜在病因。除肌肉减少组较高的移植排斥率(P=0.035)外,两组间死亡率(P=0.688)或LT术后并发症无显著差异.LT一年后，计算机断层扫描得出的身体成分参数显示,存活儿童和未存活儿童之间没有显著差异.
■我们的研究结果表明慢性肝病患儿出现少肌症的频率很高，这意味着需要更多的研究来更好地了解其对该人群临床结局的影响.
