PDF(Pubmed)
Abstract：
Polyomaviruses are a group of small, double-stranded DNA viruses that are known to be associated with the development of certain human diseases, but there is evidence that these viruses might be associated with gastrointestinal (GI) cancers. Several polyomaviruses have been identified, such as JC polyomavirus (JCPyV), BK polyomavirus (BKPyV) and recently Merkel cell polyomavirus (MCPyV). Although the direct effects of polyomaviruses on transformation of human cells and cancer development are not clearly recognized, their association with certain human diseases including GI cancers has been proposed through several molecular and epidemiological studies. For example, JCPyV and BKPyV have been linked to colorectal cancer, as there is growing evidence of finding viral genomes in cancerous tissues. Nevertheless, the major role of JCPyV, BKPyV and MCPyV in colorectal cancer progression is still under extensive investigation, and further surveys is required to establish a conclusive cause-and-effect relationship. Understanding the role of these viruses in cancer development has significant implications for diagnosis, treatment, and prevention strategies. It seems that proving a causal link between polyomaviruses and GI cancers might provide a novel path for targeted therapies or design and development of specific therapeutic vaccines. In addition, performing research on the possible link can provide insights into the underlying molecular mechanisms of carcinogenesis, potentially leading to the identification of novel biomarkers. This review focuses on polyomaviruses, in particular a recently discovered polyomavirus, MCPyV, and their possible link with human gastrointestinal disorders.
摘要：
多瘤病毒是一组小的，已知与某些人类疾病的发展有关的双链DNA病毒，但是有证据表明这些病毒可能与胃肠道（GI）癌症有关。已经鉴定出几种多瘤病毒，如JC多瘤病毒（JCPyV），BK多瘤病毒（BKPyV）和最近的默克尔细胞多瘤病毒（MCPyV）。尽管多瘤病毒对人类细胞转化和癌症发展的直接影响尚未明确认识到，已经通过一些分子和流行病学研究提出了它们与某些人类疾病包括胃肠道癌症的关联。例如,JCPyV和BKPyV与结直肠癌有关,因为越来越多的证据表明在癌组织中发现了病毒基因组。然而，JCPyV的主要角色，BKPyV和MCPyV在结直肠癌进展中的作用仍在广泛研究中，需要进一步调查以建立决定性的因果关系。了解这些病毒在癌症发展中的作用对诊断具有重要意义。治疗,和预防策略。似乎证明多瘤病毒和胃肠道癌症之间的因果关系可能为靶向治疗或设计和开发特定治疗性疫苗提供新的途径。此外,对可能的联系进行研究可以提供对致癌作用的潜在分子机制的见解，可能导致新的生物标志物的鉴定。这篇综述的重点是多瘤病毒，特别是最近发现的多瘤病毒，MCPyV,以及它们与人类胃肠道疾病的可能联系。
