PDF(Pubmed)
Abstract：
UNASSIGNED: There is no consensus on how to predict post-transplant function of donation after circulatory death (DCD) kidneys. Thus, we aimed to identify renal scintigraphy parameters that could predict 1-year kidney function.
UNASSIGNED: In this single center study, we included all consecutive DCD kidney recipients between 2013 and 2021 (n = 29). Patients who did not have a scintigraphy within 10 days of transplantation (n = 3), recipients of multiple organs and less than 18 years old were excluded (n = 1). Primary endpoint was the estimated glomerular filtration rate (eGFR).
UNASSIGNED: Median eGFR and serum creatinine at 1 year were 67 µmol/L (56-81) and 111 ml/min (99-132), respectively. Among parameters tested, the 3rd/2nd-minute activity ratio had the best diagnostic performance (AUC: 0.74 and 0.71, for eGFR and creatinine) 1 year post transplantation. Using 1.21 as the best cut off, the 3rd/2nd-minute activity ratio specificity and sensitivity to predict eGFR >60 ml/min was 0.82 and 0.83. Renal function was significantly better at 1 week, 3, 6, and 12 months after transplantation in patients with 3rd/2nd-minute activity ratios above 1.21.
UNASSIGNED: This study suggests that the 3rd/2nd-minute activity ratio can predict graft function at 1 year. The benefit of post-transplant scintigraphy should be further validated in a prospective cohort.
UNASSIGNED: In this single center study, we included all consecutive DCD kidney recipients between 2013 and 2021 (n = 29). Patients who did not have a scintigraphy within 10 days of transplantation (n = 3), recipients of multiple organs and less than 18 years old were excluded (n = 1). Primary endpoint was the estimated glomerular filtration rate (eGFR).
UNASSIGNED: Median eGFR and serum creatinine at 1 year were 67 µmol/L (56-81) and 111 ml/min (99-132), respectively. Among parameters tested, the 3rd/2nd-minute activity ratio had the best diagnostic performance (AUC: 0.74 and 0.71, for eGFR and creatinine) 1 year post transplantation. Using 1.21 as the best cut off, the 3rd/2nd-minute activity ratio specificity and sensitivity to predict eGFR >60 ml/min was 0.82 and 0.83. Renal function was significantly better at 1 week, 3, 6, and 12 months after transplantation in patients with 3rd/2nd-minute activity ratios above 1.21.
UNASSIGNED: This study suggests that the 3rd/2nd-minute activity ratio can predict graft function at 1 year. The benefit of post-transplant scintigraphy should be further validated in a prospective cohort.
摘要：
■关于如何预测循环性死亡（DCD）肾脏后捐献的移植后功能尚未达成共识。因此，我们的目的是确定可以预测1年肾功能的肾闪烁显像参数.
■在这项单中心研究中，我们纳入了2013年至2021年期间所有连续接受DCD肾脏的患者(n=29).在移植后10天内没有闪烁显像的患者（n=3），不包括18岁以下的多器官受者(n=1).主要终点是估计的肾小球滤过率（eGFR）。
■1年时eGFR和血清肌酐中位数分别为67µmol/L（56-81）和111ml/min（99-132），分别。在测试的参数中，移植后1年,第3/2分钟活动比具有最佳诊断性能(eGFR和肌酐的AUC:0.74和0.71).使用1.21作为最佳切断，预测eGFR>60ml/min的第3/2分钟活动比特异性和敏感性分别为0.82和0.83.1周时肾功能明显好转，移植后3、6和12个月，第3/2分钟活动比高于1.21的患者。
■这项研究表明，第3/2分钟的活动比可以预测1年时的移植物功能。移植后闪烁显像的益处应在前瞻性队列中进一步验证。
■在这项单中心研究中，我们纳入了2013年至2021年期间所有连续接受DCD肾脏的患者(n=29).在移植后10天内没有闪烁显像的患者（n=3），不包括18岁以下的多器官受者(n=1).主要终点是估计的肾小球滤过率（eGFR）。
■1年时eGFR和血清肌酐中位数分别为67µmol/L（56-81）和111ml/min（99-132），分别。在测试的参数中，移植后1年,第3/2分钟活动比具有最佳诊断性能(eGFR和肌酐的AUC:0.74和0.71).使用1.21作为最佳切断，预测eGFR>60ml/min的第3/2分钟活动比特异性和敏感性分别为0.82和0.83.1周时肾功能明显好转，移植后3、6和12个月，第3/2分钟活动比高于1.21的患者。
■这项研究表明，第3/2分钟的活动比可以预测1年时的移植物功能。移植后闪烁显像的益处应在前瞻性队列中进一步验证。
