PDF(Pubmed)
Abstract：
BACKGROUND: Amyloidosis is a rare disorder that can be classified into various types, and the most common type is the systemic light chain type. The prognosis of this disease is extremely poor. In general, amyloidosis mainly affects the kidneys and heart and manifests as abnormal proliferation of clonal plasma cells. Cases in which the liver is the primary organ affected by amyloidosis, as in this report, are less common in clinical practice.
METHODS: A 62-year-old man was admitted with persistent liver dysfunction of unknown cause and poor treatment outcomes. His condition persisted, and he developed chronic liver failure, with severe cholestasis in the later stage that was gradually accompanied by renal injury. Ultimately, he was diagnosed with hepatic amyloidosis through liver biopsy and pathological examination.
CONCLUSIONS: Hepatic amyloidosis rarely occurs in the clinic, and liver biopsy and pathological examination can assist in the accurate and effective diagnosis of this condition.
METHODS: A 62-year-old man was admitted with persistent liver dysfunction of unknown cause and poor treatment outcomes. His condition persisted, and he developed chronic liver failure, with severe cholestasis in the later stage that was gradually accompanied by renal injury. Ultimately, he was diagnosed with hepatic amyloidosis through liver biopsy and pathological examination.
CONCLUSIONS: Hepatic amyloidosis rarely occurs in the clinic, and liver biopsy and pathological examination can assist in the accurate and effective diagnosis of this condition.
摘要：
背景：淀粉样变性是一种罕见的疾病，可以分为各种类型，最常见的类型是系统轻链类型。这种疾病的预后极差。总的来说,淀粉样变主要影响肾脏和心脏，表现为克隆浆细胞的异常增殖。肝脏是淀粉样变性影响的主要器官的情况，在这份报告中,在临床实践中并不常见。
方法：一名62岁男性因不明原因的持续性肝功能障碍和不良治疗结果入院。他的病情持续，他出现了慢性肝衰竭,晚期伴有严重胆汁淤积，逐渐伴有肾损伤。最终,通过肝活检和病理检查诊断为肝淀粉样变性。
结论：临床上很少发生肝淀粉样变性，肝活检和病理检查可以帮助准确有效地诊断这种情况。
方法：一名62岁男性因不明原因的持续性肝功能障碍和不良治疗结果入院。他的病情持续，他出现了慢性肝衰竭,晚期伴有严重胆汁淤积，逐渐伴有肾损伤。最终,通过肝活检和病理检查诊断为肝淀粉样变性。
结论：临床上很少发生肝淀粉样变性，肝活检和病理检查可以帮助准确有效地诊断这种情况。
