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Abstract：
This study investigated variability among four indicators for quantifying antimicrobial use in intensive care units (ICUs): defined daily doses (DDD), prescribed daily doses (PDD), duration of therapy (DOT), and length of therapy (LOT) and recommended the most clinically relevant approach. Retrospective data from patients who had received at least one antimicrobial was analyzed. Patients whose records were incomplete or expired were excluded. Duration of therapy (24433/1000 PDs) and LOTs (12832/1000 PDs) underestimated the overall consumption of antimicrobials compared with DDD of 28391/1000 PDs. Whereas PDD (46699/1000 PDs) overestimated it. Comparison analysis detected % differences of 13.94, 23.92, and 54.80% between DDD and DOT, DDD and PDD, and DDD and LOT, indicators respectively. Linear regression revealed stronger (r 2 = 0.86), moderate (r 2 = 0.50), and moderate (r 2 =0.60) correlation between DDD and DOT, DDD and PDD and DDD and LOT indicators respectively. According to findings, combining DOT and DDD is a more practical method to quantify antimicrobial consumption in hospital ICUs.
UNASSIGNED: Deshwal PR, Tiwari P. Investigating the Variability among Indicators for Quantifying Antimicrobial Use in the Intensive Care Units: Analysis of Real-world Evidence. Indian J Crit Care Med 2024;28(7):662-676.
UNASSIGNED: Deshwal PR, Tiwari P. Investigating the Variability among Indicators for Quantifying Antimicrobial Use in the Intensive Care Units: Analysis of Real-world Evidence. Indian J Crit Care Med 2024;28(7):662-676.
摘要：
这项研究调查了在重症监护病房（ICU）中量化抗菌药物使用的四个指标之间的差异：定义的每日剂量（DDD），规定的每日剂量（PDD），治疗持续时间（DOT），和治疗时间（LOT），并推荐最临床相关的方法。分析了至少接受过一种抗菌药物的患者的回顾性数据。记录不完整或过期的患者被排除在外。与28391/1000PDs的DDD相比，治疗持续时间（24433/1000PDs）和LOTs（12832/1000PDs）低估了抗菌药物的总体消耗量。而PDD(46699/1000PDs)高估了它。比较分析检测到DDD和DOT之间的百分比差异为13.94、23.92和54.80%，DDD和PDD,还有DDD和LOT,指标分别。线性回归显示更强(r2=0.86)，中等(r2=0.50)，DDD和DOT之间的中度(R2=0.60)相关性，DDD和PDD以及DDD和LOT指标。根据调查结果,结合DOT和DDD是一种更实用的方法来量化医院ICU中的抗菌药物消耗。
■Deshwal公关，TiwariP.调查重症监护病房抗菌药物使用量化指标的变异性：真实世界证据分析。印度J暴击护理中心2024；28（7）：662-676。
■Deshwal公关，TiwariP.调查重症监护病房抗菌药物使用量化指标的变异性：真实世界证据分析。印度J暴击护理中心2024；28（7）：662-676。
